MedChemExpress -Model Rubusoside -64849-39-4
Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase)[1][2][3][4].MCE products for research use only. We do not sell to patients.
Rubusoside
MCE China：Rubusoside
Brand：MedChemExpress (MCE)
Cat. No.HY-N0668
CAS：64849-39-4
Purity：98.0%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase).
In Vivo：Rubusoside (50-300 mg/kg; po; single dose) exerts anti-inflammatory and antiasthmatic activities in an OVA-induced experimental allergic asthma mouse model. Moreover, Rubusoside inhibits OVA-induced activation of the NF-κB pathway in lung tissue[4].
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References：
[1]. Wang Z et al. Selective production of rubusoside from stevioside by using the sophorose activity of β-glucosidase from Streptomyces sp. GXT6. Appl Microbiol Biotechnol. 2015 Nov;99(22):9663-74. [Content Brief]
[2]. Ko JA et al. Mass production of rubusoside using a novel stevioside-specific β-glucosidase from Aspergillus aculeatus. J Agric Food Chem. 2012 Jun 20;60(24):6210-6. [Content Brief]
[3]. Zheng H, et al. Metabolomics analysis of the protective effect of rubusoside on palmitic acid-induced lipotoxicity in INS-1 cells using UPLC-Q/TOF MS. Mol Omics. 2019 Jun 1;15(3):222-232. [Content Brief]
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