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Escin

MCE China：Escin

Brand：MedChemExpress (MCE)

Cat. No.HY-B2114

CAS：6805-41-0

Purity：98.5%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Escin, a natural compound of triterpenoid saponins that can be isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.

In Vitro：Escin (1 μM, 0-5 h) stimulates phosphorylation of the GR in CFTL-12 murine mast cells[1]. Escin (0.1-1 µg/mL, 24 h) protects cells from OGD/R and rt-PA stimulaed cell damage in bEnd.3 cells[2]. Escin (0-100 μg/mL, 12-48 h) induces cell cycle arrest and apoptosis, and inhibits tumor cell proliferation in HCT116 and HCT8 cells[5]. Escin (0-80 μg/mL, 12-24 h) induces DNA damage, and upregulates p-ATM and γH2AX in HCT116 and HCT8 cells[5]. Escin (0-50 μM, 24 h) decreases mitochondrial membrane potential and induces cytochrome C release via generation of ROS, and induces apoptosis of bladder cancer cells (T24 and J82 cells )[6].

In Vivo：Escin (1-5 mg/kg, p.o.) inhibits the allergic skin response in Porcine induced by Compound 48/80 (HY-115768)[1]. Escin (0.5 and 1 mg/kg, i.v.) attenuates recombinant tissue plasminogen activator (rt-PA) induced hemorrhagic transformation (HT) in mice[2]. Escin (10 mg/kg, p.o., 4 days) shows antioxidant, anti-inflammatory, antinecrotic, and anti-apoptotic effects against Con A-induced immune-mediated hepatitis in mice[3]. Escin (5-20 mg/kg, p.o., once a day, after 6 weeks of diabetes induction, for next 4 weeks) alleviates peripheral neuropathy in Streptozotocin (HY-13753) induced diabetes in rats[4].

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References：

[1]. Sipos W, et al. Escin inhibits type I allergic dermatitis in a novel porcine model. Int Arch Allergy Immunol. 2013;161(1):44-52.  [Content Brief]

[2]. Sun X, et al. Escin avoids hemorrhagic transformation in ischemic stroke by protecting BBB through the AMPK/Cav-1/MMP-9 pathway. Phytomedicine. 2023 Nov;120:155071.  [Content Brief]

[3]. Elshal M, Hazem SH. Escin suppresses immune cell infiltration and selectively modulates Nrf2/HO-1, TNF-α/JNK, and IL-22/STAT3 signaling pathways in concanavalin A-induced autoimmune hepatitis in mice. Inflammopharmacology. 2022 Dec;30(6):2317-2329.  [Content Brief]

[4]. Suryavanshi SV, Kulkarni YA. Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats. Life Sci. 2020 Aug 1;254:117777.  [Content Brief]

[5]. Wang Z, et al. Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway. Acta Pharmacol Sin. 2018 Oct;39(10):1645-1660.  [Content Brief]

[6]. Cheng CL, et al. Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study. Eur J Pharmacol. 2018 Dec 5;840:79-88.  [Content Brief]