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Delphinidin 3-glucoside chloride

MCE China：Delphinidin 3-glucoside chloride

Brand：MedChemExpress (MCE)

Cat. No.HY-108052

CAS：6906-38-3

Synonyms：Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride

Purity：99.89%

Storage：-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL). Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM. Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 µM. Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction.

In Vitro：Delphinidin 3-glucoside chloride (30-100 μM) induces cell apoptosis in B CLL cells through redox-sensitive caspase 3 activation[1]. Delphinidin 3-glucoside chloride (0-40 μM) exhibits inhibitory activity towards breast cancer cells and carcinogen-induced breast carcinogenesis, through downregulation of the HOTAIR expression via pAKT/IRF1 signaling pathway[4]. Delphinidin 3-glucoside chloride (1-100 μM) inihibits the oxLDL-induced endothelial dysfunction in HUVECs with dependence of Sodium-Dependent Glucose Transporter (SGLT1)[5]. Delphinidin 3-glucoside chloride (0-50 μM) inhibits ADP, collagen or TRAP stimulated platelet aggregation through inhibition of AMPK phosphorylation[6].

In Vivo：Delphinidin 3-glucoside chloride (40 mg/kg/day, i.g. for 25 days) inhibits tumor growth in MDA-MB-231-Luc-GFP xenografted athymic BALB/c mice [4]. Delphinidin 3-glucoside chloride (50 μM, i.v.) inhibits thrombus growth in FeCl3 induced mesenteric arteriole injury in C57BL/6 mice[6].

IC50 & Target：IC50: 2.37 µM (EGFR)[3] In Vitro Delphinidin 3-glucoside chloride (30-100 μM) induces cell apoptosis in B CLL cells through redox-sensitive caspase 3 activation[1]. Delphinidin 3-glucoside chloride (0-40 μM) exhibits inhibitory activity towards breast cancer cells and carcinogen-induced breast carcinogenesis, through downregulation of the HOTAIR expression via pAKT/IRF1 signaling pathway[4]. Delphinidin 3-glucoside chloride (1-100 μM) inihibits the oxLDL-induced endothelial dysfunction in HUVECs with dependence of Sodium-Dependent Glucose Transporter (SGLT1)[5]. Delphinidin 3-glucoside chloride (0-50 μM) inhibits ADP, collagen or TRAP stimulated platelet aggregation through inhibition of AMPK phosphorylation[6]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Delphinidin 3-glucoside chloride Related Antibodies Apoptosis Analysis[1] Cell Line: B CLLs

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References：

[1]. Mahmoud Alhosin, et al. Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway. Sci Rep. 2015 Mar 11;5:8996.  [Content Brief]

[2]. Naoki Nanashima, et al. Phytoestrogenic Activity of Blackcurrant Anthocyanins Is Partially Mediated through Estrogen Receptor Beta. Molecules. 2017 Dec 29;23(1):74.  [Content Brief]

[3]. Candice Mazewski, et al. Comparison of the effect of chemical composition of anthocyanin-rich plant extracts on colon cancer cell proliferation and their potential mechanism of action using in vitro, in silico, and biochemical assays. Food Chem. 2018 Mar 1;242:378-388.  [Content Brief]

[4]. Yang X, et al., Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway. BMC Cancer. 2016 Jul 7;16:423.  [Content Brief]

[5]. Jin X, et al., Delphinidin-3-glucoside protects against oxidized low-density lipoprotein-induced mitochondrial dysfunction in vascular endothelial cells via the sodium-dependent glucose transporter SGLT1. PLoS One. 2013 Jul 18;8(7):e68617.  [Content Brief]

[6]. Yang Y, et al., Plant food delphinidin-3-glucoside significantly inhibits platelet activation and thrombosis: novel protective roles against cardiovascular diseases. PLoS One. 2012;7(5):e37323.  [Content Brief]