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MedChemExpressModel Moracin C - 69120-06-5

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Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells[1].
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Moracin C

MCE China:Moracin C

Brand:MedChemExpress (MCE)

Cat. No.HY-N3245

CAS:69120-06-5

Purity:99.54%

Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells.

In Vitro:Moracin C (1-50 μM, 24 h) inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from RAW264.7 cells[1]. Moracin C (1-50 μM, 2 h) inhibits mRNA and protein expression of iNOS and COX-2 in RAW264.7 cells[1]. Moracin C (1-50 μM, 2 h) inhibits pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) productions in LPS-activated RAW 264.7 cells[1]. Moracin C (1-50 μM, 2 h) inhibits phosphorylation of p38, ERK and JNK in LPS-activated RAW 264.7 cells[1].

In Vivo:Moracin C (100 mg/kg, oral gavage, mice) was rapidly and well absorbed in the intestinal tract, and was highly distributed in the gastrointestinal tract, liver, kidneys, and lungs[2].

IC50 & Target:COX-2

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References:

[1]. Yao X, et al. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci. 2016 Jul 25;17(8):1199.  [Content Brief]

[2]. You BH, et al. Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Jul;87(8):642-651.  [Content Brief]

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