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MedChemExpress - Model Human serum ...

MedChemExpress - Model Human serum albumin - 70024-90-7

Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO−) in the vascular wall, contributing to the reduction of blood pressure[1][2][3].

Human serum albumin

MCE China：Human serum albumin

Brand：MedChemExpress (MCE)

Cat. No.HY-P1956

CAS：70024-90-7

Synonyms：HSA

Purity：99.9%

Storage：-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO−) in the vascular wall, contributing to the reduction of blood pressure.

In Vitro：HAS (5 μM, 0-90 minutes) can bind with Glycerol Monolaurate (GML), with a Kd value of 1.4 μM. HSA can prevent the ability of GML to inhibit human T cells and protect the function of T cells[3]. HSA (0.01, 0.05, 0.1 μM, 0-24 h) alleviates the GML-induced phosphorylation of AKT at threonine 308 and serine 473 residues as well as the formation of LAT, PLC-γ1, and AKT microclusters, and restores the production of IFN-γ, IL-2, IL-10, and TNF-α in GML-treated cells[3].

In Vivo：Human serum albumin (10 ml/kg; Intravenous injection; Once at 1 hour and once at 5 hours; twice) partially prevents the oxidative stress induced by LPS (HY-D1056) (50 mg/kg) in male Swiss mouse models, as well as the decrease in blood pressure due to upregulation of NF-κB, iNOS, and peroxynitrite (ONOO−) in the vascular wall[4]. Human serum albumin (10 ml/kg; Intravenous injection; Once at 1 hour and once at 5 hours; twice) in a Male Swiss mouse model completely prevented endotoxin-induced reduced vascular response to phenol catecholamines, electromyotonia, and endothelial dysfunction, and reduced inflammatory processes leading to oxidative and nitrite stress and reduced vascular reactivity[4].

IC50 & Target：iNOS

References：

[1]. Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med. 2018 Jun;52:8-12. [Content Brief]

[2]. Fanali G, et al. Human serum albumin: from bench to bedside. Mol Aspects Med. 2012 Jun;33(3):209-90. [Content Brief]

[3]. Zhang MS, et al. Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function. PLoS One. 2016;11(10):e0165083. Published 2016 Oct 20. [Content Brief]

[4]. Meziani F, et al. Human serum albumin improves arterial dysfunction during early resuscitation in mouse endotoxic model via reduced oxidative and nitrosative stresses. Am J Pathol. 2007;171(6):1753-1761. [Content Brief]

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