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L-Cysteine hydrochloride hydrate

MCE China：L-Cysteine hydrochloride hydrate

Brand：MedChemExpress (MCE)

Cat. No.HY-W016715

CAS：7048-04-6

Purity：98.0%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：L-Cysteine hydrochloride hydrate is an orally active and essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate regulates CBS/H2S pathway, inhibits NF-κB activation and insulin and ghrelin secretion. L-Cysteine hydrochloride hydrate reduces blood sugar, vascular inflammation markers and appetite. L-Cysteine hydrochloride hydrate induces kidney damage. L-Cysteine hydrochloride hydrate can be used in the study of neurological diseases and diabetes.

In Vitro：L-Cysteine hydrochloride (5 mM, 5-7 days) hydrate inhibits Aspergillus flavus growth and AFB1 synthesis by disrupting cell structure and antioxidant system balance[2]. L-Cysteine (1-10 μM, 1-5 days) hydrochloride hydrate promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway[3]. L-Cysteine (3 mM, 1 h) hydrochloride hydrate inhibits insulin release from the pancreatic β-Cell[4].

In Vivo：L-Cysteine (500-2000 mg/kg/day, p.o., daily, 28 consecutive days) hydrochloride hydrate exhibits renal injuries such as basophilic tubules with eosinophilic material in the lumen in rats[5]. L-Cysteine (50 mg/kg, i.p., 7 days) hydrochloride hydrate only marginally alleviates lead-induced toxicity in albino mice[6]. L-Cysteine (1-4 mmol/kg, p.o.) hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents (rats and mice)[7]. L-Cysteine (1 mg/kg, p.o., daily, 8 weeks) hydrochloride hydrate can lower glycemia and markers of vascular inflammation in diabetes apparently by preventing NF-κB activation in a diabetic rat model[8]. L-Cysteine (1000 mg/kg, i.v., daily) hydrochloride hydrate suppresses body weight gain, decreases spontaneous activity, salivation, ptosis, tremor in male Sprague-Dawley rats[9].

IC50 & Target：Microbial Metabolite Human Endogenous Metabolite

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References：

[1]. McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond). 2015 Mar;39(3):447-55.  [Content Brief]

[2]. Qiu M, et al. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB1 synthesis by disrupting cell structure and antioxidant system balance. J Hazard Mater. 2023 Oct 5;459:132218.  [Content Brief]

[3]. Wang Z, et al. L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H₂S pathway. Neuroscience. 2013 May 1;237:106-17.  [Content Brief]

[4]. Kaneko Y, et al. L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. Diabetes. 2006 May;55(5):1391-7.  [Content Brief]

[5]. Shibui Y, et al. Comparisons of l-cysteine and d-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration. J Toxicol Pathol. 2017 Jul;30(3):217-229.  [Content Brief]

[6]. Mahmoud YI, et al. Effects of L-cysteine on lead acetate induced neurotoxicity in albino mice. Biotech Histochem. 2016 Jul;91(5):327-32.  [Content Brief]

[7]. McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond). 2015 Mar;39(3):447-55.  [Content Brief]

[8]. Jain SK, et al. L-cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-kappaB activation in the livers of Zucker diabetic rats. Free Radic Biol Med. 2009 Jun 15;46(12):1633-8.  [Content Brief]

[9]. Jain S K, et al. L-Cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-κB activation in the livers of Zucker diabetic rats. Free Radical Biology and Medicine, 2009, 46(12): 1633-1638.