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MedChemExpress - Model Atractylenolide ...

MedChemExpress - Model Atractylenolide III - 73030-71-4

Atractylenolide III (ICodonolactone) is the main component of Atractylodes rhizome and has the activity of inducing apoptosis in lung cancer cells. Atractylenolide III is an orally active gastroprotective agent[1][2][3].

Atractylenolide III

MCE China：Atractylenolide III

Brand：MedChemExpress (MCE)

Cat. No.HY-N0203

CAS：73030-71-4

Synonyms：ICodonolactone; 8β-Hydroxyasterolide

Purity：99.94%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Atractylenolide III (ICodonolactone) is the main component of Atractylodes rhizome and has the activity of inducing apoptosis in lung cancer cells. Atractylenolide III is an orally active gastroprotective agent.

In Vitro：Atractylenolide III (1-100 μM, 48 h ) induces cell apoptosis, and induces the activation of caspase-3 and caspase-9 and cleavage of PARP in A549 cells[1]. Atractylenolide III (1-100 μM, 72 h) inhibits proliferation and angiogenesis (tube formation) in HUVECs[1]. Atractylenolide III (1-100 μM) inhibits thymic stromal lymphopoietin (TSLP)-induced production of proinflammatory cytokines (IL-6, IL-1b, TNF-α, and IL-8) in HMC-1 cells[4].

In Vivo：Atractylenolide III (5 and 10 mg/kg, p.o.) shows gastroprotective effects and reduces 70% ethanol-induced gastric ulcer in rats[2]. Atractylenolide III (30 mg/kg, oral gavage for 14 days or 28 days) reduces depressive- and anxiogenic-like behaviors in rat depression models in Lipopolysaccharide (LPS) (HY-D1056) and chronic unpredictable mild stress (CUMS) induced rat depression model[5].

References：

[1]. Kang TH, et al. Atractylenolide III, a sesquiterpenoid, induces apoptosis in human lung carcinoma A549 cells via mitochondria-mediated death pathway. Food Chem Toxicol. 2011 Feb;49(2):514-9. [Content Brief]

[2]. Wang KT, et al. Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo. J Pharm Pharmacol. 2010 Mar;62(3):381-8. [Content Brief]

[3]. Kim HK, et al. Toxicity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus. J Agric Food Chem. 2007 Jul 25;55(15):6027-31. [Content Brief]

[4]. Yoou MS, et al. Ameliorative effect of atractylenolide III in the mast cell proliferation induced by TSLP. Food Chem Toxicol. 2017 Aug;106(Pt A):78-85. [Content Brief]

[5]. Zhou Y, et al. Atractylenolide III reduces depressive- and anxiogenic-like behaviors in rat depression models. Neurosci Lett. 2021 Aug 10;759:136050. [Content Brief]

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