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Florfenicol

MCE China：Florfenicol

Brand：MedChemExpress (MCE)

Cat. No.HY-B1374

CAS：73231-34-2

Synonyms：(-)-Florfenicol; SCH-25298

Purity：99.73%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Florfenicol ((-)-Florfenicol) is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions[6][7].

In Vitro：Florfenicol (0.025, 0.1, 0.4 mg/mL, 48 h) inhibits fibroblast proliferation and autophagy by inducing mitochondrial dysfunction[1]. Florfenicol (0.097-200 μg/mL, 24 h) exhibited cytotoxic effects on Unio crusus and Cyprinus carpio primary cell lines and reduced primary cell viability[2].

In Vivo：Florfenicol (10-90 mg/kg, p.o.) exhibits toxicity to developing chicks and can induce early embryonic death[3]. Florfenicol (0.15 g/L, 5 days, p.o.) induces renal inflammatory response and cell apoptosis in chicks by activating the cell adhesion molecule signaling pathway[4]. Florfenicol (30 mg/kg, 8 days, p.o.) exhibits regulatory effects on lymphocyte subsets and humoral immune responses in sheep red blood cell immunized broiler chickens[5]. Florfenicol (5, 25, 100 mg/kg, 4 days, p.o.) inhibits allergic airway inflammation in mice through p38 MAPK mediated GATA 3 phosphorylation [6]. Florfenicol (50, 100, 200 mg/kg, 10 days, p.o.) can inhibit humoral and cellular immune responses in mice[7].

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References：

[1]. Hu D, et al. Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts. Sci Rep. 2017 Oct 19;7(1):13554.  [Content Brief]

[2]. Arslan P, et al. In vitro effects of erythromycin and florfenicol on primary cell lines of Unio crassus and Cyprinus carpio. Environ Sci Pollut Res Int. 2021 Sep;28(35):48408-48416.  [Content Brief]

[3]. Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11:213.

[4]. Wang X, et al. Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway. Poult Sci. 2022 Nov;101(11):102152.  [Content Brief]

[5]. Lis M, et al. Modulation of lymphocyte subsets and humoral immune response by florfenicol administered to sheep red blood cell-immunized broiler chickens. Pol J Vet Sci. 2019 Dec;22(4):481-487.  [Content Brief]

[6]. Xinxin C, et al. Florfenicol inhibits allergic airway inflammation in mice by p38 MAPK-mediated phosphorylation of GATA 3. Clin Immunol. 2011 Feb;138(2):231-8.  [Content Brief]

[7]. Shuang G, et al. Immunosuppressive activity of florfenicol on the immune responses in mice. Immunol Invest. 2011;40(4):356-66.  [Content Brief]