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MedChemExpress LLC (MCE)
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MedChemExpress - Model Cedrol - 77-53-2

MedChemExpress - Model Cedrol - 77-53-2

Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties[1][2][3][4][5][6][7].

Cedrol

MCE China：Cedrol

Brand：MedChemExpress (MCE)

Cat. No.HY-N2071

CAS：77-53-2

Synonyms：(+)-Cedrol; α-Cedrol

Purity：99.76%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties.

In Vitro：Cedrol (0-450 μM; 24-72 h) inhibits HT-29 and CT-26 cell proliferation in a dose - and time-dependent manner, with IC50 values of 138.91 and 92.46 µM, respectively[4]. Cedrol (0-225 μM; 0-48 h) induces cell cycle arrest in G0/G1 phase by regulating the expression of cell cycle regulators CDK4 and cyclin D1 and apoptosis through both exogenous (FasL/caspase-8) and endogenous (Bax/caspase-9) pathways in HT-29 and CT-26 cells[4]. Cedrol (0-180 µM; 48 h) combined with 5-FU (HY-90006) significantly decreases HT-29 cell viability[4].

In Vivo：Cedrol (150 mg/kg; Subcutaneous injection; Once every two days; 20 days) has antitumor effect in mouse model of colorectal cancer[4]. Cedrol (200-1600 mg/kg; Intraperitoneal injection; Single dose; 30 minutes before the test) exerts anti-anxiety effects in female mice through the 5-hydroxyindoleacetic or dopamine system[5]. Cedrol (50-200 mg/kg; Topical application; 27 days) prevents alopecia in a mouse model of hair loss induced by Cyclophosphamide (HY-17420)[6]. Cedrol (20-40 mg/kg; Intraperitoneal injection; Once a day; 14 days) relieves neuropathic pain by inhibiting oxidative stress and inflammation in a rat model of chronic contractile injury[7].

IC50 & Target：CYP2 CYP3

References：

[1]. Jeong HU, et al. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77(22-24):1522-32. [Content Brief]

[2]. Jin MH, et al. Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner. Ann Dermatol. 2012 Feb;24(1):16-21 [Content Brief]

[3]. Özek G, et al. Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species. Molecules. 2021 Dec 16;26(24):7644. [Content Brief]

[4]. Chien JH, et al. Cedrol restricts the growth of colorectal cancer in vitro and in vivo by inducing cell cycle arrest and caspase-dependent apoptotic cell death. Int J Med Sci. 2022 Oct 31;19(13):1953-1964. [Content Brief]

[5]. Zhang K, et al. Anxiolytic Effect of Cedrol on Behavior and Brain Neurotransmitter Levels of Female Mice. Biol Pharm Bull. 2019 Sep 1;42(9):1575-1580. [Content Brief]

[6]. Chen SS, et al. Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice. Environ Toxicol Pharmacol. 2016 Sep;46:270-276. [Content Brief]

[7]. Sakhaee MH, et al. Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation. Metab Brain Dis. 2020 Oct;35(7):1119-1126. [Content Brief]

Brand introduction:
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