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MedChemExpress - Model Hydroxysafflor yellow A - 78281-02-4

Hydroxysafflor yellow A (Safflomin A) is a natural product of flavonoids isolated from safflower. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. Hydroxysafflor yellow A has anti-inflammatory, antioxidant and antitumor effects. Hydroxysafflor yellow A can be used in the study of cardiovascular disease[1][2][3][4][5][6].

Hydroxysafflor yellow A

MCE China：Hydroxysafflor yellow A

Brand：MedChemExpress (MCE)

Cat. No.HY-N0567

CAS：78281-02-4

Synonyms：Safflomin A; HSYA

Purity：99.17%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Hydroxysafflor yellow A (Safflomin A) is a natural product of flavonoids isolated from safflower. Hydroxysafflor yellow A can inhibit cell proliferation and promote apoptosis through the autophagy pathway. Hydroxysafflor yellow A has anti-inflammatory, antioxidant and antitumor effects. Hydroxysafflor yellow A can be used in the study of cardiovascular disease.

In Vitro：Hydroxysafflor yellow A (10 μM, 24 h) Inhibition of LPS-induced proliferation and migration of vascular smooth muscle cells by toll-like receptor-4 pathway[1]. Hydroxysafflor yellow A (0.01-10 mg/L, 4-96 h) can promote the expression of fat-soluble specific enzyme HSL by increasing the activity of HSL promoter and inhibit the proliferation and adipogenesis of 3T3-L1 preadipocytes[2]. Hydroxysafflor yellow A (1-100 μM), 12-24 h) decreases LPS-induced EC inflammatory damage by inhibiting p38 MAPK phosphorylation, NF-κB activation, high expression of inflammatory factors and leukocyte adhesion to EC[3]. Hydroxysafflor yellow A (20-160 μM, 24-48 h) inhibits cell proliferation and promotes apoptosis by blocking the autophagy flux in liver cancer cells[6].

In Vivo：Hydroxysafflor yellow A (2.5 or 10 mg/kg/day, intraperitoneal injection for 6 weeks) protects the liver from long-term alcohol damage by enhancing antioxidant capacity and inhibiting TGF-β1 expression[4]. Hydroxysafflor yellow A (30, 48, 76.8 mg/kg, intraperitoneal injection) has a protective effect on inflammatory damage in rats with chronic obstructive pulmonary disease by reducing NF-κB and p38MAPK signal transduction[5]. Hydroxysafflor yellow A (1.135, 2.25 mg/kg, intraperitoneal injection) can inhibit tumor growth and block autophagy of liver cancer cells in tumor models of nude mice[6].

References：

[1]. Yang G, et al. Hydroxysafflor yellow A inhibits lipopolysaccharide-induced proliferation and migration of vascular smooth muscle cells via Toll-like receptor-4 pathway. Int J Clin Exp Med. 2015 Apr 15;8(4):5295-302. [Content Brief]

[2]. Zhu HJ, et al. Hydroxysafflor yellow A (HYSA) inhibited the proliferation and differentiation of 3T3-L1 preadipocytes. Cytotechnology. 2015 Oct;67(5):885-92. [Content Brief]

[3]. Jin M, et al. Hydroxysafflor yellow A attenuate lipopolysaccharide-induced endothelium inflammatory injury. Chin J Integr Med. 2016 Jan;22(1):36-41. [Content Brief]

[4]. He Y, et al. Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats. J Physiol Biochem. 2015 Mar;71(1):69-78. [Content Brief]

[5]. Jin M, Xue et al. Protective Effect of Hydroxysafflor Yellow A on Inflammatory Injury in Chronic Obstructive Pulmonary Disease Rats. Chin J Integr Med. 2019 Oct;25(10):750-756. [Content Brief]

[6]. Wu N, et al. Hydroxysafflor yellow A promotes apoptosis via blocking autophagic flux in liver cancer. Biomed Pharmacother. 2021 Apr;136:111227. [Content Brief]

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