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MedChemExpress - Model Resolvin D2 - ...

MedChemExpress - Model Resolvin D2 - 810668-37-2

Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

Resolvin D2

MCE China：Resolvin D2

Brand：MedChemExpress (MCE)

Cat. No.HY-121636

CAS：810668-37-2

Synonyms：RvD2

Purity：99.00%

Storage：Solution, -20°C, 2 years

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons.

In Vivo：Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions[1]. Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression[2]. Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain[3].

IC50 & Target：TRP Channel[3] In Vivo Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions[1]. Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression[2]. Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult CD1 mice (male, 8–10 weeks)[3]

References：

[1]. Siddiqui YD, et al. Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. Front Immunol. 2019 Feb 26;10:307. [Content Brief]

[2]. Spite M, et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29;461(7268):1287-91. [Content Brief]

[3]. Park CK, et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.6. J Neurosci. 2011 Dec 14;31(50):18433-8. [Content Brief]

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