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MedChemExpress - Model Tellimagrandin ...

MedChemExpress - Model Tellimagrandin II - 81571-72-4

Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases[1][2][3][4].

Tellimagrandin II

MCE China：Tellimagrandin II

Brand：MedChemExpress (MCE)

Cat. No.HY-N9386

CAS：81571-72-4

Synonyms：Eugeniin

Purity：98.81%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases.

In Vitro：Tellimagrandin II (40 µg/mL, 24 hours) disrupts the cell wall integrity of Staphylococcus aureus[2]. Tellimagrandin II (40 μg/mL, 5 hours) significantly inhibits mecA mRNA and PBP2a protein expression in Methicillin-Resistant Staphylococcus aureus[2]. Tellimagrandin II (50 μM, 6 hours) significantly inhibits LPS (HY-D1056)-induced NO production as well as NOS2 mRNA and protein expression in RAW264.7 cells[3]. Tellimagrandin II (25 or 50 μM, 12 hours) significantly inhibits LPS (HY-D1056)-induced COX-2 protein levels and PGE2 production in RAW264.7 cells[3]. Tellimagrandin II (12.5-50 μM, 10 minutes) shows significant AChE inhibitory activity, with the IC50 of 18.6 μM[4]

In Vivo：Tellimagrandin II (100 and 200 mg/kg, p.o., once daily for 10 days) improved learning and memory functions in Scopolamine (HY-N0296)-induced amnesiac ICR mice[4].

References：

[1]. Ruth Niemetz, et al. Oxidation of pentagalloylglucose to the ellagitannin, tellimagrandin II, by a phenol oxidase from Tellima grandiflora leaves. Phytochemistry. 2003 Feb;62(3):301-6. [Content Brief]

[2]. Yu-Wei Chang, et al. Tellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureus. Int J Mol Sci. 2019 Nov 18;20(22):5790. [Content Brief]

[3]. Lin CY, et al. Lipopolysaccharide-Induced Nitric Oxide and Prostaglandin E2 Production Is Inhibited by Tellimagrandin II in Mouse and Human Macrophages. Life (Basel). 2021 Apr 30;11(5):411. [Content Brief]

[4]. Chen LG, et al. Hydrolysable Tannins Exhibit Acetylcholinesterase Inhibitory and Anti-Glycation Activities In Vitro and Learning and Memory Function Improvements in Scopolamine-Induced Amnesiac Mice. Biomedicines. 2021 Aug 23;9(8):1066. [Content Brief]

Brand introduction:
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•   The biological activity of the products has been verified by the experiments of customers in various countries；
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