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Levistolide A

MCE China：Levistolide A

Brand：MedChemExpress (MCE)

Cat. No.HY-N1472

CAS：88182-33-6

Purity：99.26%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Levistolide A is an apoptosis inducer and a PEDV virus inhibitor. Levistolide A can induce apoptosis in colon cancer cells and suppress the replication of porcine epidemic diarrhea virus (PEDV) by promoting ROS generation. Levistolide A activates peroxisome proliferator-activated receptor γ (PPARγ) in N2a/APP695swe cells and reduces excessive phosphorylation of tau through the GSK3α/β pathway, improving symptoms in Alzheimer’s mice. Levistolide A improves kidney damage in 5/6 nephrectomy (Nx) mice by inhibiting the RAS,TGF-β1/Smad, and MAPK pathways.

In Vitro：Levistolide A (50, 100 μM; 24 h) induces apoptosis in colon cancer cells by promoting ROS generation and mediating the endoplasmic reticulum stress pathway[1]. Levistolide A (1.1, 3.3, 10 μg/mL) activates peroxisome proliferator activated receptor gamma (PPARγ) in N2a/APP695swe cells and reduces tau hyperphosphorylation through the GSK3 α/β pathway, thereby reducing the production and aggregation of β - amyloid protein (A β)[2]. Levistolide A (20-80 μM; 36 h) can inhibit the replication of Porcine Epidemic Diarrhea Virus (PEDV) by inducing ROS generation[3].

In Vivo：Levistolide A (2 mg/kg; once every two days; i.p.) can improve memory deficits and cognitive abilities in Alzheimer's disease mice, and reduce inflammatory responses in the brain[2]. Levistolide A (0.5-2 mg/kg; once every two days; 4 weeks; i.p.) improves renal fibrosis and injury in 5/6 nephrectomy (Nx) mice by inhibiting the expression of key molecules in the RAS, TGF - β 1/Smad, and MAPK pathways[4].

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References：

[1]. Yang Y, et al. Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells. Cell Physiol Biochem. 2017;42(3):929-938.  [Content Brief]

[2]. Qu X, et al. Levistolide A Attenuates Alzheimer's Pathology Through Activation of the PPARγ Pathway. Neurotherapeutics. 2021 Jan;18(1):326-339.  [Content Brief]

[3]. Zeng W, et al. Levistolide A Inhibits PEDV Replication via Inducing ROS Generation. Viruses. 2022 Jan 27;14(2):258.  [Content Brief]

[4]. Aobulikasimu N, et al. Levistolide A ameliorates fibrosis in chronic kidney disease via modulating multitarget actions in vitro and in vivo. Life Sci. 2023 May 1;320:121565.  [Content Brief]