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Dextran

MCE China：Dextran

Brand：MedChemExpress (MCE)

Cat. No.HY-112624

CAS：9004-54-0

Synonyms：Dextran 40

Purity：95.0%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.

In Vivo：Dextran can be used in animal modeling to create paw edema models. Injection of dextran at doses of either 7.9 mg/kg or 300 mg/kg results in edema of equal intensity in the limbs[1][2]. .f12{ font-size: 12px; } .fwb{ font-weight: bold; } .lh22{ line-height: 22px;; } .lh23 { line-height: 23px; } .pl13{ padding-left: 13px;; } .part { margin-top: 18px; } .mold-first-tit { width: 100%; height: 44px; line-height: 44px; background: #F9F7FB; border-bottom: 1px solid #EBE4F6; padding-left: 16px; box-sizing: border-box; margin-bottom: 17px; } .mold-second-tit:before { content:""; width: 6px; height: 6px; display: inline-block; border-radius: 50%; background: rgba(255,102,0,0.4); margin-right: 12px; position: relative; top: -3px; } .lft-border { border-left: 1px dotted #EBE4F6; padding-right: 12px; margin-left: 3px; box-sizing: border-box; padding-bottom: 12px; } /* .part .dec:last-child { border-bottom: 0; } */ .dec { margin: 10px 15px 0; padding-bottom: 10px; border-bottom: 1px dashed #EBE4F6; } .btm-border { border-left: 1px dashed #EBE4F6; } .text-bg { margin-top: 10px; background: #FFFBF1; padding: 14px; border-bottom: 0; position: relative; } .text-note-bg { margin-top: 10px; background: #FFFDF7; padding: 12px; border-bottom: 0; position: relative; } .text-note { width: 51px; height: 20px; line-height: 20px; background: #FFE2AA; text-align: center; border-radius: 0 0 8px 0; position: absolute; top: 0; left: 0; } .text-note-dec { margin-top: 15px;; } Induction of paw edema[1][2]. Background Dextran promotes the release of histamine and serotonin from mast cells during edema formation. These substances alter the tone and vascular permeability, contributing to fluid extravasation[1][2]. Specific Mmodeling Methods Mice: Swiss albino• male • weighing 25-30 g[1].Administration: 1% dextran (20 μL/paw)• intraplantar injection in the right hind paw• a single dose for 1, 2, 3 and 4 h[1].Rat: Albino of of the Sprague Dawleq strain• weighing 110-130 g• seven-week-old[2].Administration: 0.5 mL/100 g • tail vein injection• a single dose[2]. Note (1)Dextran (6% v/w in saline) was freshly diluted each day so as to contain 7.9 mg or 600 mg per 5 ml volume of physiological saline[2]. Modeling Indicators Morphological change: Developed marked inflammatory reaction and significantly increased the volume of paw edema[1].Histological analysis: Mast-cell disruption (histamine and serotonili release), vasodilatation, hypothermia, hypotension, helnoconcentration and edema occurred with the high doses of Dextran. Since minute doses of dextran induced only vasodilatation and edema formation[2]. Correlated Product(s): Carrageenan (HY-125474); Histamine (HY-B1204); Arachidonic acid (HY-109590)[1]. Opposite Product(s): /

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References：

[1]. Santos ES, et al. Anti-inflammatory activity of herb products from Licania rigida Benth. Complement Ther Med. 2019 Aug;45:254-261.  [Content Brief]

[2]. GOEZSY B, et al. INVESTIGATIONS INTO THE MECHANISM OF DEXTRANINDUCED EDEMA IN RATS. Can J Biochem Physiol. 1963 Sep;41:1855-63.  [Content Brief]

[3]. REDEI A. Investigations on the mechanism of dextran induced oedema in rats. Med Exp Int J Exp Med. 1962;6:73-8.  [Content Brief]

[4]. Bark BP, et al. Infusion rate and plasma volume expansion of dextran and albumin in the septic guinea pig. Acta Anaesthesiol Scand. 2014 Jan;58(1):44-51.  [Content Brief]