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MedChemExpressModel FG-3019 - 946415-13-0

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FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF)[1][2].
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FG-3019

MCE China:FG-3019

Brand:MedChemExpress (MCE)

Cat. No.HY-P99288

CAS:946415-13-0

Synonyms:Pamrevlumab; Anti-Human CTGF Recombinant Antibody

Purity:99.0%

Storage:Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping:Shipping with dry ice.

Description:FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF).

In Vivo:FG-3019 (30 mg/kg; i.p. every 3 d for 9 d) in combination with Gemcitabine acutely decreases mouse pancreatic ductal adenocarcinoma (PDA) growth and induces neoplastic cell apoptosis in LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) mice[2].

Species:Human

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References:

[1]. Sgalla G, et, al. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2020 Aug;29(8):771-777.  [Content Brief]

[2]. Neesse A, et, al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12325-30.  [Content Brief]

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