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MedChemExpress - Model 2,4-Di-tert-butylphenol - 96-76-4

2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of medicines and fragrances[1][2][3].

2,4-Di-tert-butylphenol

MCE China：2,4-Di-tert-butylphenol

Brand：MedChemExpress (MCE)

Cat. No.HY-W014589

CAS：96-76-4

Synonyms：2,4-DTBP

Purity：99.99%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of medicines and fragrances.

In Vitro：2,4-Di-tert-butylphenol (10 μM; 14 d) can increase adipogenesis in human mesenchymal cells, with the same effect as PPARγ agonist (500 nM; 14 d)[2].2,4-Di-tert-butylphenol (10 μM; 14 d) can also increase adipogenesis that is blocked by PPARγ antagonist T0070907 (HY-13202) (10 μM) or RXRα antagonist HX531 (HY-108521) (1 μM)[2].2,4-Di-tert-butylphenol can also activate PPARγ and RXRα in human COS-7 cells[2].

In Vivo：2,4-Di-tert-butylphenol (300 mg/kg/day; po; 28 d) causes hepatotoxicity (associated with centrilobular hypertrophy of hepatocytes, which results in liver weight gain) and nephrotoxicity in rats, and increases cholesterol and phospholipids in female rats[2].2,4-Di-tert-butylphenol (5-40 mg/kg/day; po; 28 d) can significantly attenuate Aβ1-24-induced cognitive impairment and exert an anti-amnestic effect[3].

IC50 & Target：Human Endogenous Metabolite RXR α

References：

[1]. Zhao F, et al. Natural sources and bioactivities of 2, 4-di-tert-butylphenol and its analogs[J]. Toxins, 2020, 12(1): 35. [Content Brief]

[2]. Ren XM, et al. 2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors. Endocrinology. 2023 Feb 11;164(4):bqad021. [Content Brief]

[3]. Choi SJ, et al. 2,4-Di-tert-butylphenol from sweet potato protects against oxidative stress in PC12 cells and in mice. J Med Food. 2013 Nov;16(11):977-83. [Content Brief]

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