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2A Pharma - Model 2AP04 - Anti-Amyloid-Beta Vaccine Candidate
From2A Pharma ApS
2A Pharma’s anti-amyloid-beta vaccine candidate, AAVLP-Amyloid-β, has in laboratory tests with transgenic mice over-expressing amyloid-beta mutant protein been shown to eliminate amyloid-beta soluble protein, a clear plaque from the cortex and significantly reduce plaque from the hippocampus. It is our hope that the drug candidate can be developed into a treatment for early-stage Alzheimer’s disease.
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- Induces A?? specific antibodies recognizing monomeric and aggregated forms of human amyloid-beta
- Decreases levels of soluble A?? peptides and plaque load in brain of hAPP transgenic mice