SystImmune -Model BL-M07D1-ADC -Antibody Drug Conjugates (ADC) Molecules
FromSystImmune Inc.
Antibody Drug Conjugates (ADC) molecules utilize specific antibodies to deliver therapeutic small molecules specifically to cancer cells. ADC are created in cooperation with Bai-Li Pharmaceutical’s R&D Center of Excellence and enable the development of sophisticated chemistries that give this class of drugs their therapeutic payload. This advanced functional class is referred to as Heterogeneity overcoming - Immunogenic death inducing - Resistance antagonizing - Enhanced Specificity (HIRE) molecules that target cancer cells.
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The ADC BL-M07D1 is a HER2 specific antibody based on the drug Trastuzumab. Due to its HER2 binding, BL-M07D1 has anti-proliferative effects in a variety of HER2 driven solid tumors and secondarily, through a wt FC receptor can mediate innate immune effector functions toward the cancer cells. Upon antibody mediated internalization, BL-M07D1 is trafficked to cancer cell lysosomes and liberates its therapeutic payload that induced genotoxic stress activating pathways leading to cancer cell death.
BL-M07D1 is currently being evaluated as a single agent in clinical trials enrolling patients with a variety of HER2+ solid tumor indications.
