SystImmune -Model BL-M11D1-ADC -Antibody Drug Conjugates (ADC) Molecules
FromSystImmune Inc.
Antibody Drug Conjugates (ADC) molecules utilize specific antibodies to deliver therapeutic small molecules specifically to cancer cells. ADC are created in cooperation with Bai-Li Pharmaceutical’s R&D Center of Excellence and enable the development of sophisticated chemistries that give this class of drugs their therapeutic payload. This advanced functional class is referred to as Heterogeneity overcoming - Immunogenic death inducing - Resistance antagonizing - Enhanced Specificity (HIRE) molecules that target cancer cells.
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The ADC BL-M11D1 is a CD33 specific antibody based on the drug Gemtuzumab.Due to its CD33 binding, BL-M11D1 has specificity toward CD33 expression hematopoietic malignancies including AML.The BL-M11D1 is engineered to have an IgG wt FC receptor allowing for the mediation of innate immune effector functions toward the cancer cells. Upon antibody mediated internalization, BL-M11D1 is trafficked to cancer cell lysosomes and liberates its therapeutic payload that induced genotoxic stress activating pathways leading to cancer cell death.
BL-M11D1 is currently being evaluated as a single agent in clinical trials enrolling patients with a variety of CD33+ hematopoietic malignancies.
BL-M11D1 is currently being evaluated as a single agent in clinical trials enrolling patients with a variety of CD33+ hematopoietic malignancies.
