Atmo - Gastrointestinal Gas-Sensing Capsule
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Technology
Within the Atmo Gas Capsule's 2cm-long polymer shell are gas sensors, a temperature sensor, a microcontroller, a radio-frequency transmitter, and button-sized silver-oxide batteries. The gas sensors are sealed within a special membrane that allows gas in but keeps out stomach acid and digestive juices.
The technology works by using sensors to measure different gases by adjusting their heating elements, and the data can then be transmitted to a mobile phone. Oxygen concentrations are used to track the capsule's progress throughout the GI tract.
Data is transmitted in real-time to a small receiver that can be carried in a pocket or left on the nightstand when someone is home. The receiver in turn transmits the data via Bluetooth to a cell phone, which can post the data online for easy monitoring by users and doctors.
Features
- Tracks location and evaluates constituents (%) of H₂, O₂, CO₂, CH₄ gas present as the capsule travels through the GI tract.
- Will soon measure H₂S and short-chain fatty acids
- Uses O₂ to track location
- Temp sensor tells patient via phone app when capsule has exited
- Data to receiver to phone to cloud
- Data sent every 5 minutes for 72 hours
Human Clinical Trials
Human Clinical Trials
Phase 1 human clinical trials have been successfully completed on 23 people.
Clinical trials of the Atmo Gas Capsule were conducted on 23 healthy participants adhering to either a low- or high-fibre diet. Results showed that the capsule is safe and reliable, and accurately shows the onset of food fermentation, highlighting their potential to clinically monitor digestion and normal gut health. The trials also demonstrated that the Atmo Gas Capsule could offer a much more effective way of measuring microbiome activities in the stomach, a critical way of determining gut health.
The current method for measuring gas biomarkers is using breath tests. Breath tests, however, are an indirect measurement technique requiring the gases that are generated in the gut to be absorbed into the blood stream, circulated around the body, transferred into the lungs and finally exhaled out of the mouth. For this reason breath tests show low specificity and sensitivity when compared to the direct method used by the Atmo Gas Capsule.
Key Benefits
The Atmo Biosciences Gas Capsule has a unique set of benefits that could revolutionise the way gut disorders and diseases are diagnosed and managed.
- Direct sensing : At the source of gas production within the gut
- Greater accuracy : Up to 10,000 times better than current standards
- Data : Patient data can be aggregated for clinical analysis and predictive algorithms
- Low cost : Cheaper than all current methods
- Non-invasive : Patients go about their normal life
- Small : The size of a common vitamin pill
- Real-time data collection : Data transmitted wirelessly to receiver, phone app and cloud in real-time from known location in the gut
- Future opportunities : Potential applications span malabsorption to IBD
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