Augurex - Model 14-3-3 - Protein Citrullination Analysis
Citrullination is a highly relevant post-translational modification of proteins that occurs in RA and certain other conditions. In the extracellular space, 14-3-3η becomes citrullinated (cit) in the presence of peptidylarginine deiminases (PAD) enzymes and this extracellular modified form of the protein, cit-14-3-3η, also elicits an auto-immune response that generates cit-14-3-3η specific auto-antibodies. Both the cit-14-3-3η protein and the cit-14-3-3η auto-antibodies are measurable in blood and their clinical utility is a fast-paced area of ongoing clinical research at Augurex.
Product Details
Risk of RA
Diagnosis
- 14-3-3η is a Novel Mediator Associated with the Pathogenesis of Rheumatoid Arthritis and Joint Damage
- Review: 14-3-3η – a Novel Biomarker Platform for Rheumatoid Arthritis
- Serum 14-3-3η is a Novel Marker that Complements Current Serological Measurements to Enhance Detection of Patients with Rheumatoid Arthritis
- 14-3-3η Autoantibodies: Diagnostic Use in Early Rheumatoid Arthritis
- The Diagnostic Value of 14-3-3η Protein Levels in Patients with Rheumatoid Arthritis
- Serum 14-3-3η Protein is Associated with Clinical and Serologic Features of Sjögren’s Syndrome in Patients with Systemic Lupus Erythematosus: A Cross-Sectional Analysis
Prognosis
- Serum Levels of 14-3-3η Protein Supplement C-reactive Protein and Rheumatoid Arthritis-Associated Antibodies to Predict Clinical and Radiographic Outcomes in a Prospective Cohort of Patients with Recent-Onset Inflammatory Polyarthritis
- Impending Radiographic Erosive Progression Over the Following Year in a Cohort of Consecutive Patients with Inflammatory Polyarthritis: Prediction by Serum Biomarkers
Monitoring
- Serum 14-3-3η Level is Associated with Severity and Clinical Outcomes of Rheumatoid Arthritis, and its Pretreatment Level is Predictive of DAS28 Remission with Tocilizumab
- Decrease in 14-3-3η Protein Levels is Correlated with Improvement in Disease Activity in Patients with Rheumatoid Arthritis Treated with Tofacitinib
- Correlation of Plasma 14-3-3η Levels with Disease Activity Measures in Methotrexate-Naïve RA Patients Treated with Upadacitinib Monotherapy in the Select-Early Phase 3 Study
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