BioHAnce Technology for Pet Healthcare

FromDômes Pharma Inc (formely Sentrx™ Animal Care)

BioHAnce technology represents a significant advancement in the field of veterinary healthcare, particularly focusing on ophthalmology and epidermal repair solutions. By employing advanced bioengineering techniques, BioHAnce has created a molecular matrix of crosslinked hyaluronic acid (HA), which is specifically tailored for different tissue environments such as ocular and skin surfaces. This innovative approach addresses the limitations of naturally occurring HA, which degrades rapidly, restricting its practical application. The BioHAnce matrix provides a stable environment that enhances hydration, supports natural healing processes, and extends its functional duration in tissues. The technology involves no active pharmaceutical ingredients, instead utilizing a hydrogel scaffold that actively promotes healing. Additionally, BioHAnce products are purified to eliminate side components that might trigger immune responses, ensuring excellent biocompatibility. The platform also allows the crosslinking of different molecules, enhancing its versatility and utility in conjunction with other therapeutic treatments.

Patented and proprietary.

BioHAnce technology uses advanced bioengineering to create a molecular matrix of crosslinked hyaluronic acid (HA) that can be specifically modified for each formulation and particular tissue environment, including ocular and skin surfaces. It produces a cellular scaffolding with unique physical and chemical properties that enhances hydration, accelerates the body’s own healing processes and extends duration in tissue.

Bioengineered to effectiveness and duration.

HA is a naturally occurring substance throughout the body of humans and animals that plays a key role in hydration, tissue lubrication and healing processes. Before BioHAnce, the rapid degradation of naturally occurring HA limited its clinical applications and efficacy in the real world. This patented technology makes it possible to chemically modify the HA so it is more resistant to degradation, while providing an ideal environment to enhance natural healing processes, hydration and lubrication. This bioengineering technology also makes it possible to specifically design an optimal HA matrix for a particular tissue environment.

The key benefits of crosslinked HA:

Extends duration in ocular and dermal surfaces
Accelerates the body’s own healing process
Enhances hydration and lubrication in tissue
Creates a thin barrier that soothes and protects
Can be tailored to match the specific tissue environment
Unlike many veterinary products that are derived from human treatments, Sentrx biomaterials are created specifically for animals

Our BioHAnce technology is a purified product. No side components that have any detrimental or toxic byproducts or irritating effects. Traditional cross-link technologies use a process that can result in poor biocompatibility, an elevated immune response or inflammation.

Crosslinked vs Non-Crosslinked HA Products

Cross-linking creates a more viscous lubrication at a lower concentration. It also has muco-adhesive properties that a base HA molecule does not. Thus it stays on surfaces longer and does
not get cleared from the eye during blinking like traditional HA eye drops do.
Once you cross-link HA, it changes the chemical and physical properties of HA. Thus you can’t compare the concentration of an HA product to the concentration of a cross-linked HA product. The cross-linking process effectively creates an infinite molecular weight and thus the physical properties are different.
The higher the molecular weight of a product the harder it is to get into solution. Our cross-linked formulation nearly creates an infinite molecular weight but allows for scaling, purification and sterile filtration.

A platform technology

In addition, the chemically functionalized polymers (a molecule made from joining together many small molecules) in this platform technology can be crosslinked to a variety of other molecules. Not only does this make Sentrx products effective alone, they may be used in conjunction with other treatments to deliver growth factors, drugs, or autologous cells.

How it’s made.

BioHAnce is created by making two modifications to hyaluronic acid. We purchase medical grade hyaluronic acid made by a fermentation process that is free of animal products, which is modified and purified prior to use in our dermal and ocular formulations. Certificates of Analysis for all raw materials are kept at our facility as part of our documentation procedure. Following the final purification, the solution of BioHAnce is sterile filtered and aseptically crosslinked to form the final HA gel product.