bit.bio - Human-induced Glutamatergic Neurons
From Cell Products
ioGlutamatergic Neurons have been reprogrammed from human induced pluripotent stem cells (iPSC) using our precise reprogramming technology: opti-ox™¹ (optimized inducible overexpression). Human stem cells, within days, convert into consistent, mature, functional glutamatergic neurons providing a high quality human model for the study of neurological activity and disease.
Details
ioGlutamatergic Neurons consist mainly of glutamatergic neurons (>80%) characterised by the expression of the glutamate transporter genes VGLUT1 and VGLUT2. The minor remaining fraction of the neuronal population express marker genes of cholinergic neurons. A bulk RNA-seq analysis shows that ioGlutamatergic Neurons have a rostral CNS identity and express the classical cortical marker genes FOXG1 and TBR1 (data not shown).
Ready-to-culture cells are suitable as models for research in cell-type specific biology, target validation and drug screening in pharmaceutical R&D, and toxicology testing.
Applications:
- Academic research
- Drug development
- Neurotoxicology
- High-throughput screening
- Single cell CRISPR Screening
- 3D bioprinting
Customer reviews
No reviews were found for bit.bio - Human-induced Glutamatergic Neurons. Be the first to review!