BostonGene - Bioinformatic Technology
The BostonGene platform integrates informatics, genomics, transcriptomics, and microenvironment analysis to empower personalized decisions and the delivery of optimized therapeutics.
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Molecular cancer diagnosis
The BostonGene Tumor Portrait™ Test depicts tumor activity, cellular composition, the immune microenvironment, and other associated processes to identify activated or suppressed pathways within tumors to guide therapeutic decision-making.
Gene expression
Accurate measurement of expression of more than 100,000 transcripts and 20,000 genes, including splice variants, with RNA-Seq.
Neoantigens
Tumor antigenicity is measured by calculating the expression of neoantigenic peptides in mutated and fusion proteins.
Clonal evolution
NGS-driven analysis of each sample’s mutational profile aims to determine the number of tumor clones and their ratios. Understanding tumor clonal composition can detect resistance mutations ahead of time and prevent disease regression.
TCR/BCR repertoire profiling
BostonGene cancer reactive profiling of T and B cells immune cell repertoire in the tumor microenvironment in solid cancer as well as the identification of major malignant clones of T and B cells in hematological malignancies leads to a better understanding of tumor progression and evolution.
Pathway analysis
Analyzing functional and transcriptomic effects of genomic alterations by utilizing complete spectrum of protein-protein interactions in a comprehensive map of signaling pathways.
Virus & Bacteria infection detection
BostonGene detects cancer-associated viral or bacterial infections as these are incredibly important for diagnostics and therapy selection.
Genomic alterations
Using tumor and matched-normal samples, whole-exome sequencing detects point mutations, insertions, copy number alterations, tumor mutational burden (TMB), homologous recombination deficiency (HRD), genomic instability, and loss of heterozygosity (LOH).
Tumor microenvironment
BostonGene reconstructs the tumor microenvironment using the Kassandra algorithm, capable of calculating the cellular composition of the tumor microenvironment from bulk RNA-Seq data.
Fusion
Detecting novel and recurrent gene fusions.
Applications
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Genetic Testing for Patients - Medical / Health Care
With many cancers, genetic testing is recommended at the time of diagnosis. Genetic testing reveals important features, including mutations and other specific markers for treatment response. Some of these features can be targeted by therapies. The results from your genetic testing can help your provider personalize treatment plans to target specific features of your cancer.
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Solutions for Physicians Providers - Medical / Health Care
BostonGene’s integrated approach solution provides a holistic 360° overview for each cancer patient. Our clinical pipeline distinguishes more than 62 cancer types and 129 subtypes, compressing all the information you need into one simple patient-specific report. “A report built by physicians for physicians”.
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Solutions for Researchers - Medical / Health Care - Medical Research
BostonGene supports academic researchers and life science companies to build a future without cancer. As a research partner, BostonGene provides access to a wide spectrum of cutting-edge technologies to develop and validate novel precision medicine approaches.
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Solutions for Pharma - Medical / Health Care - Pharmaceuticals
BostonGene supports biopharma companies at any stage of product development
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