Caladrius - Model CLBS12 - Critical Limb Ischemia (CLI)
Also known as Chronic Limb-Threatening Ischemia (CLTI). Critical limb ischemia (CLI) is an advanced form of peripheral arterial disease (PAD) caused by a severe blockage in the arteries of the lower extremities. PAD is caused by atherosclerosis, the hardening and narrowing of the arteries over time due to the buildup of fatty deposits called plaque. CLI is a chronic condition that results in severe pain in the feet or toes, even while resting. Complications can include sores and wounds on the legs and feet that won’t heal due to the lack of circulating blood (carrying oxygen) essential to our body’s healing process. Left untreated, the complications of CLI can result in amputation of the affected limb.
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Buerger’s disease is a rare disease of the arteries and veins in the arms and legs. In Buerger’s disease – also called thromboangiitis obliterans – your blood vessels become inflamed, swell and can become blocked with blood clots. This eventually damages or destroys skin tissues and may lead to infection and gangrene (the death or decay of body tissues).(1). In some cases, amputation may be required. (2).
Our Approach: CLBS12
The goal of treatment with HONEDRA®, an experimental regenerative medicine, is to prevent the serious adverse consequences of CLI and Buerger’s disease by improving blood flow in the affected limb.
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