Creative Enzymes - Model PHAM-235 - Native Bovine Aprotinin
From Medical Enzymes- Pharmaceutical Enzymes
Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or < 3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.
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Products Details
- Abbr Aprotinin (Bovine)
- Alias aprotinin; Trasylol
- Source Bovine lung
- Species Bovine
- Bio-activity Not < 3.0 units/mg, calculated on the dried basis.
- CAS No. 9087-70-1
- Appearance White or almost white powder
- pH Stability 5.0-7.0
- Applications 1. In clinical, used in the prevention andtreatment of acute pancreatitis, hemorrhage and disseminated intravascularcoagulation caused by fibrinolysis. 2. It can prevent or delay the developmentof pulmonary interstitial edema (shock lung), and its inhibition has a dose andtime dependent. 3. After abdominal surgery, injected directlyinto the abdominal cavity can prevent intestinal adhesion.
- Synonyms aprotinin; Trasylol; bovine pancreatic trypsin inhibitor BPTI; 9087-70-1
- Loss on drying < 6.0%
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