Model DTH Series -Delayed-type Hypersensitivity

Delayed-type hypersensitivity (DTH) model can be used for rapid screening of anti-inflammatory compounds.The DTH-model is performed by sensitizing mice with a sensitizing agent (e.g. Oxazolone) on the abdomen and a week later challenge of the ears with the sensitizing agent. An acute DTH response occurs on the ears and can be followed by measuring the ear thickness, which is signicantly increased and sustained for up to 7 days.