Elabscience - Model PTEN -E-AB-40284 - Polyclonal Antibody
From Cancer Research Antibodies
In order to facilitate the operation and ensure the accuracy of WB results, the Western Blot Detection kit (Cat# E-IR-R304) is now available, containing the reagents which are needed from sample preparation to result detection. Please order the appropriate kit according to your specific needs.
Separating gel 10%
- Separating gel 10%
- Transfer Membrane 150mA, 1.5h
- Blocking 1.5h
- Primary Antibody 1:500
- Secondary Antibody 1:5000
Product Details
- Clonality Polyclonal
- Isotype IgG
- Concentration 0.89 mg/mL
- Storage Store at -20℃. Avoid freeze / thaw cycles.
- Buffer PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
- Purification Method Antigen Affinity Purification
- Research Areas Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
- Conjugation Unconjugated
Immunogen Details
- Immunogen Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN protein(PKSH033828)
- Abbre PTEN
- Synonyms 10q23del,BZS,DEC,GLM2,MGC11227,MHAM,MMAC1,MMAC1 phosphatase and tensin homolog deleted on chromosome 10,Mutated in multiple advanced cancers 1,Phosphatase and tensin homolog,Phosphatase and tensin like protein,Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN,Pten,PTEN,PTEN1,TEP1
- Swissprot P60484
- Gene ID 5728
- Calculated MW 65,47,20 kDa
- Observed MW 68 kDa
- Cellular Localization Secreted.Nucleus
- Tissue Specificity Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
Background
PTEN (also designated MMAC1),products of tumor suppressor genes,are found deleted in most human gliomas. The PTEN genes are also mutated in many other tumors,such as brain,breast,kidney and prostate cancers. PTEN is a protein tyrosine phosphatase that may terminate the signaling transduction pathways mediated by PI 3-kinase/Akt. PTEN has an apparent molecular weight of 55 kDa and it is located in the cytosol.
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