EmulSol - Nano-Emulsion Technology
From Technology
EmulSol is a technology for production of oil-in-water nano-emulsions. Nano-emulsions have droplet sizes in the range of 50 to 500 nanometers, and are stable for the intended shelf-life of the product. Ascendia produces nano-emulsions using a high-shear homogenization process. After a suitable oil phase is chosen (based on chemical compatibility and solubility with the drug substance), a mixture of the oil, water, and the drug substance is processed through the homogenizer creating a fine suspension of the oil droplets in a water phase. As the drug substance is significantly more soluble in the oil phase, than in the water phase, the vast majority of the drug is solubilized within the interior of the oil droplets. Thus when the nano-emulsion is delivered to the body, the drug substance is more readily bioavailable.
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Product Details
Ascendia’s nano-emulsion process is novel in that it uses no organic co-solvents, and a minimal amount of surfactant excipients. By minimizing surfactants, and eliminating solvents, Ascendia’s nano-emulsions are suitable for pharmaceutical applications. A nano-emulsion can greatly reduce the irritation and injection site pain for a parenterally delivered product. A nano-emulsion can be used to develop a topical formulation with superior clarity and bioavailability properties. In addition, nano-emulsions can be dehydrated and incorporated into solid oral dosage forms.
Ascendia specializes in the application of nano-technology approaches to develop novel pharmaceutical products. Our suite of state-of-the-art technologies for formulating poorly water soluble compounds provides sophisticated formulation options for our clients. Contact us today for more information on how our formulations can enable your pharmaceutical product.
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