Extracellular Vesicle Therapy
Aegle’s founder Dr. Evangelos Badiavas and his team have spent decades researching clinical applications of mesenchymal stem cells (“MSCs”) in severe dermatological disorders, including conducting clinical trials in burns and wounds under multiple INDs. In these trials, patients experienced accelerated healing, little to no scarring, total wound closure and tissue regeneration. However, given that MSCs are hard to predict and control in vivo, compounded by the high costs of production, Dr. Badiavas and his team set out to discover ways to harness the healing power of stem cells without using the cells.
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The science directed their research to exosomes, or extracellular vesicles (“EVs”). Adult human MSCs secrete EVs – these EVs function as the paracrine wound healing mediators of their “parent” cells. EVs express membrane proteins and contain RNA, DNA, peptides, proteins and metabolites of their host cell of origin. EVs transport their cargo and fuse into target cells, delivering the messages of the host cell, and alter the function and physiology of the target cell. Like stem cells, extracellular vesicles stimulate and enhance neuronal regeneration, cellular proliferation, cellular migration, and functional regeneration and organization of complex tissue structures in vivo. EVs have also been shown to deliver missing genetic material to diseased or damaged cells, correcting the functionality of the cells. In addition, extracellular vesicles are not alive like cells. They do not migrate, differentiate, proliferate or engraft, addressing some of the more complex issues surrounding stem cell therapy.
Aegle was founded on the concept of using EVs isolated from allogeneic bone marrow-derived MSCs as therapy. EV therapy can be administered both topically and as a local area injection. EVs have higher production yields than stem cells and given their stability have lower handling costs.
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