Futura - Model TIB200 - Topical Ibuprofen Pain Relief Gel
From Development Stage
TIB200 is a topical 10% ibuprofen gel for pain relief that utilises Futura's DermaSys® technology. DermaSys® enables ibuprofen to be delivered rapidly and efficiently through the skin. Local application and rapid, efficient absorption translate into a fast onset of action, and the potential for twice-daily dosing.
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How TIB200 Works?
1. Application of gel with ibuprofen
Combination of solvents, including volatile solvents.
2. Seconds later
Volatile solvents evaporate, leaving the remaining solvent supersaturated with ibuprofen.
Supersaturation drives ibuprofen rapidly through the skin.
3. Minutes later
Ibuprofen penetrates the skin rapidly to reach the site of action.
Clinical Data Showing Efficacy and Safety Profile
In early in vitro studies and in an in vivo clinical study DermaSys® showed significant superiority in terms of skin penetration of ibuprofen. TIB200, a topical gel combining the well-known analgesic ibuprofen with the DermaSys® delivery system, has been shown to achieve superior penetration through human skin compared with other commercially available topical ibuprofen gels.
In a proof of concept study in a model of UV-induced erythema and pain, the efficacy and safety of TIB200 was assessed against a market-leading ibuprofen gel, oral ibuprofen, as well as a placebo gel. TIB200 outperformed both topical and oral comparators, and placebo.
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