Genmab DuoBody - Model CD3xB7H4 (GEN1047) - Proprietary Bispecific Antibody
DuoBody-CD3xB7H4 (GEN1047) is a proprietary bispecific antibody created using Genmab’s DuoBody® technology. B7H4 is an immune checkpoint protein expressed on malignant cells in various solid cancers including breast, ovarian and lung cancer. In preclinical studies, DuoBody-CD3xB7H4 was shown to induce T-cell mediated cytotoxicity of B7H4-positive tumor cells.
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Clinical Trials
A phase 1 clinical study of DuoBody®-CD3xB7H4 in solid tumors is ongoing.
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