Gritstone - HIV Therapeutic Vaccine
From Our Pipeline
We have a collaboration established with Gilead Sciences to research and develop a vaccine-based immunotherapy as part of Gilead’s efforts to cure patients with human immunodeficiency virus (HIV) infection. The companies are developing an HIV-specific therapeutic vaccine using Gritstone’s proprietary prime-boost vaccine platform, comprised of self-amplifying mRNA (samRNA) and adenoviral vectors.
Products Details
Gritstone has conducted preclinical studies with our prime-boost vaccine technology utilizing simian immunodeficiency virus (SIV) derived antigens as model antigens. These antigens are very similar to those in HIV-1. The data demonstrated strong, durable and broad anti-SIV CD8+ T cell responses and T cell memory data. Gritstone and Gilead jointly performed further preclinical experiments that generated additional compelling data on the vaccine platform’s potential utility against HIV, and the companies are preparing to advance the program into a Phase 1 clinical trial.
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