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IdeaHGI - Human Gastro-Intestinal Simulator
IdeaHGI is a Human GastroIntestinal Simulator, a dynamic in-vitro model of the human gastrointestinal tract with controlled environmental condition (pH, temperature, optional ORP, stirring, …).
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Three configurations are available:
- DUO - 2 (gastric chamber + small intestine or gastro-intestinal digestion + colon fermentation)
- TRIO - 3 compartments (gastric chamber + duodenal chamber + jejunal chamber);
- COMPLEX - 5 compartments (gastric chamber + small intestine + 3 regions of the large intestine (ascending, transverse and descending colon)).
IdeaHGI can be used for studying physicochemical, enzymatic and microbial parameters in the gastrointestinal tract (e.g. bioaccessibility of micro- & macronutrients, digestibility, lipid oxidation, survival of probiotics) and as a multi-compartmental dissolution apparatus to measure the dissolution rate of pharmaceutical solid dosage forms;