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Synergy -In Vivo Bone Healing Technology

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Data Driven Performance - In Vivo Study Results; Bioactive glass has typically been used in a particulate form consisting of irregular particles and a broad size range (32-710 um).  Instead of creating a bone graft with these "off-the-shelf" particles, Synergy utilized a unique spherical particle shape and conducted an in vivo optimization study to determine the size range that provided the best bone healing. Testing in a rabbit bone defect model showed that the Putty composed of 10:90 mix of 90-180 um spheres and 355-500 um spheres provided the best healing.

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  • At 6 weeks, BioSphere® Putty showed complete healing with bone formation throughout the entire implant area. By comparison, the competitive products showed progressing bone formation only
    at the periphery of the defect.
  • By 12 weeks, the BioSphere Putty showed that the new bone was remodeling and had the appearance of the surrounding bone.  The 12 week images for the competitive products showed additional bone formation, but there was still a void at the center of the defe