Ion GeneStudio - Model S5 - Next-Generation Sequencing (NGS) System
Expand your research to cover 2M to 130M sequencing reads per run with this scalable platform. The Ion GeneStudio S5 systems are designed to enable a broad range of targeted next-generation sequencing (NGS) applications with speed and scalability. Five Ion S5 chips enable a sequencing throughput range of 2M to 130M reads per run.
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Cancer Research
Enabling NGS analysis and discovery of multi-biomarker types (fusions, insertion/deletions (indels), single nucleotide variants, and copy number variations), Oncomine assays are part of an end-to-end workflow that includes simple, scalable sequencing with optimized bioinformatics and reporting—designed for cancer research.
Peripheral blood TCRB repertoire convergence and c...
Approach: Leverage the low substitution error rate of the Ion Torrent platform to evaluate convergence as a predictive biomarker for response to anti-CTLA-4 monotherapy in a set of 22 individuals with cancer. Eight peripheral blood leukocyte (PBL) samples derived from three donors were analyzed using the Oncomine TCRB-LR assay or Sequenta/Adaptive Biotechnologies TCRB assay.
Results: The combination of TCR evenness and convergence improves prediction of response (AUC = .89).
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