Betalin -Islet Transplantation Technology

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Islet transplantation is a widely used cell therapy technique which achieves normoglycemia (normal blood glucose levels) in diabetic patients. However, one of the biggest challenges is early islet cell death, this tends to occur before the transplantation procedure. This is thought to be due to the loss of the islets microenvironment during isolation. The extracellular matrix (ECM, a support network for your tissues and organs) has been shown to be critical for the functioning and viability of islet cells. 

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Even though islet transplantation has proven successful, around 2-3 transplantations will need to be performed to reach normoglycemia. In addition over time, beta cells lose their function resulting in patients needing to go back on insulin therapy.