Blood Brain Equipment
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Manufactured by SynVivo, Inc.based in USA
SynBBB blood-brain barrier model recreates the in vivo microenvironment by replicating a histological slice of brain tissue cells. The model is able to do this by communicating with endothelial cells across the blood-brain barrier (BBB). As a result, shear-induced endothelial cell tight junctions are easily ...
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Manufactured by Creative Peptidesbased in USA
Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism oflevodopa. This property is significant in that it allows a greater proportion of peripheral levodopa to cross the blood–brain barrier for central nervous system ...
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Manufactured by MitoImmune Therapeutics Inc.based in SOUTH KOREA
The blood-brain barrier (BBB) penetrating technology is essential to develop drugs for neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease, which have high unmet medical needs. MitoImmune has developed BIM Technology, a central nervous system target technology, and is conducting ...
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Manufactured by Reglagene Holding, Inc.based in USA
RGNXXXX is a potent, orally administered, blood-brain barrier penetrant therapy that is being optimized for the treatment of anti-infectivity and neuro-inflammation, such as acute COVID-19 and neuro-inflammatory diseases, respectfully. ...
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by Vaxxinitbased in USA
findings, and immunogenic, with a high responder rate and antibodies that cross the blood-brain barrier ...
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Manufactured by ScienCell Research Laboratoriesbased in USA
Brain microvascular endothelial cells (BMEC), the major component of the blood-brain barrier, limit the passage of soluble and cellular substances from the blood into the brain. BMEC have unique features to distinguish themselves from those of peripheral endothelial cells, such as 1) intercellular tight junctions ...
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Manufactured by OPKO Health, Inc.based in USA
hydrolyzes at physiological pH and body temperature, releasing the intact drug in a controlled manner. Depending on the peptide or protein, the released molecule can either work locally, systemically or cross the blood brain barrier at receptor ...
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Manufactured by Reglagene Holding, Inc.based in USA
RGN3118 is a potent, orally administered, blood-brain barrier penetrant therapy that has been optimized for the treatment of high-grade gliomas, such as glioblastoma as well as brain metastases from breast, lung, and melanoma cancers. ...
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Manufactured by Diverse Biotech Incbased in USA
Specific Advantages of Conjugate Platform: Potential Step increase in efficacy. Rapid absorption and distribution. Increased lipophilicity (cross blood–brain barrier). Effective to >10x the current standard of care. Potential to lower dose of current highly-toxic therapeutic agents in the market ...
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Manufactured by CanaQuest Medical Corp.based in CANADA
Mentanine®, supported by (cannabidiol “CBD” + IP formula) – molecules bond and synergistically attach to PPAR receptors allowing the formula to cross the blood-brain barrier (BBB) to target the central nervous system (the brain) with amplified effects and efficacy. CBD by itself did not do this in the ...
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Manufactured by Pascal Biosciences Inc.based in USA
combined with other chemotherapeutics. However, unlike PAS-403, none of these agents cross the blood-brain barrier and therefore have no activity on glioblastoma or other brain ...
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Manufactured by Tempo Bioscience, Incbased in USA
Blood Brain Barrier (BBB) is an important feature of the cerebral vasculature. Cells that form the barrier are called Brain Microvascular Endothelial Cells (BMECs). The barrier regulates the transport of molecular chemicals (including metabolites) and cells between the brain and blood. The barrier’s ...
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based in USA
Researchers and scientists have spent the last 25 years trying and failing to develop effective treatments for brain diseases. The majority of the traditional treatments methods available can’t bypass the blood brain barrier, leaving the majority of the medication behind in the nasal cavity, sinuses, or GI tract. Other methods also ...
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Manufactured by True Phantom Solutions Inc. (TPS)based in CANADA
Bifurcation for R&D is a feature which can be implemented to any location of the brain/blood vessels or simply submerged in a brain mimicking material used to fill the skull or head phantom. . The features shown on the image is made out of our proprietary blood vessel mimicking material with realistic acoustical and MRI ...
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Manufactured by ALZET Osmotic Pumpsbased in USA
Many agents do not cross the blood-brain barrier sufficiently to evaluate their effects on the brain without delivering them locally. Cerebral injection is one local delivery method, but it can be challenging to deliver an effective dose in a physiologically-compatible volume. In addition, the agent may not remain in the target location ...
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Manufactured by GELITA AGbased in GERMANY
. It is one of the primary structural proteins of connective tissues and also abundant in blood vessels, intervertebral discs, the blood-brain barrier, the cornea, dentin and the intestinal wall – a vital component of our whole ...
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Manufactured by Medical Instruments Spabased in ITALY
The TRUE FLOW RDB cannula is designed to be used during ascending aorta and arch procedures when antegrade selective cerebral perfusion (ASCP) is needed. Its unique features allow a safe positioning, low risk of displacement and optimal blood flow to the brain. It is available in different ...
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Manufactured by Jan Medical, Inc.based in USA
At the beginning of the cardiac cycle the brain vasculature is draining the blood from the previous diastole. The new surge of blood into the brain arrives via the carotid arteries that originate from the aortic arch, distributing blood into all areas of the brain. The blood flow ...
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Manufactured by DiamiRbased in USA
(e.g. synapses and neurites). microRNAs can cross the blood-brain barrier and be detected in the bloodstream. Development of neurodegenerative and other neurological diseases is often accompanied by synapse dysfunction and/or loss. Thus, microRNAs enriched in the brain, present in synapses and detectable in plasma can be powerful and ...
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Manufactured by Virpax Pharmaceuticalsbased in USA
time in the nares promoting delivery via the olfactory route across the blood brain barrier and into the central nervous ...
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