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Genomic Editing Equipment & Supplies
22 equipment items found
Manufactured by:ASC Therapeutics based inMilpitas, CALIFORNIA (USA)
Genome editing technologies enables permanent modifications to the genome by harnessing the activities of certain enzymes (e.g. nucleases and integrase) and invoking DNA repair mechanisms at specific locations in the genome. As a therapeutic modality, genome editing can correct a defective gene, ...
by:Caribou Biosciences, Inc. based inBerkeley, CALIFORNIA (USA)
Our next-generation chRDNA genome-editing platform is the foundation for the development of differentiated allogeneic cell therapies. Our chRDNA technology enables multiple genome edits, including multiplex gene insertions, with a high degree of specificity and lower levels of off-target editing than first ...
Manufactured by:Integrated DNA Technologies, Inc. based inCoralville, IOWA (USA)
The Alt-R CRISPR-Cas9 System includes all of the reagents needed for successful genome editing based on the natural S. pyogenes CRISPR-Cas9 system. Discover what makes the Alt-R CRISPR-Cas9 system best in ...
by:Intellia Therapeutics, Inc. based inCambridge, MASSACHUSETTS (USA)
Genome editing is efficient, precise and scalable. CRISPR/Cas9 genome editing can make permanent, precisely targeted changes in patients’ chromosomes and repair the underlying genetic mutation, whereas more traditional gene therapy typically involves introducing a non-permanent copy of a gene into patients’ cells. ...
Manufactured by:Locus Biosciences, Inc. based inMorrisville, NORTH CAROLINA (USA)
CRISPR-Cas3 offers a unique approach to human genome editing with the ability to produce long-range deletions. Our IP portfolio enables the use of Cas3 human gene editing, a capability that we have been incubating since the inception of Locus. The ability to produce long-range deletions makes it possible to inactivate and/or remove of undesirable ...
Manufactured by:Cellomics Technology, LLC based inHalethorpe, MARYLAND (USA)
eSpCas9 (enhanced specificity Cas9) has enhanced specificity compared to wild type Cas9 for CRISPR/Cas9 genome editing. eSpCas9 is able to reduce off-target effects and maintain robust on-target genome editing efficiency, allowing more efficient gene targeting. eSpCas9 (CAG, Neo) lentivirus expresses eSpCas9 under the control of ...
Manufactured by:Metagenomi based inEmeryville, CALIFORNIA (USA)
Ultra-small nucleases to expand in vivo delivery options; Our ultra-small nucleases are highly efficient genome editing systems that have the potential for extensive therapeutic applications. We have prioritized finding systems to overcome the size constraints of ...
by:Vor Biopharma based inCambridge, MASSACHUSETTS (USA)
Our first multi-targeted Treatment System is comprised of VOR33-CLL1 multiplex-edited eHSC therapy and VCAR33-CLL1 multi-specific CAR-T therapy. Knocking out CD33 and CLL-1 through gene editing offers a promising new approach to treating patients with AML using our novel eHSC platform. Our research demonstrates that multiplex genome ...
by:Intellia Therapeutics, Inc. based inCambridge, MASSACHUSETTS (USA)
The first patient was dosed with our investigational genome editing treatment for transthyretin (ATTR) amyloidosis in November 2020. Our modular approach enables us to optimize the power and versatility of the CRISPR/Cas9 technology and, importantly, allows us to rapidly develop therapeutics for numerous diseases that currently have limited treatment ...
by:Caribou Biosciences, Inc. based inBerkeley, CALIFORNIA (USA)
We are developing differentiated, off-the-shelf CAR-T cell therapies, derived from healthy donor T cells, that are genome-edited to improve persistence of antitumor activity and potential therapeutic benefit. ...
Manufactured by:Metagenomi based inEmeryville, CALIFORNIA (USA)
Genomic replacements and insertions; Metagenomi’s RIGS make programmable genomic modifications that are encoded in RNA templates. Using RIGS we can achieve small edits (prime editing), as well as large edits. Our RIGS platform allows us to ...
Manufactured by:SBI System Biosciences, LLC based inPalo Alto, CALIFORNIA (USA)
Use this first-generation SBI EF1α-hspCas9 SmartNickase when you want to reduce off-target events, have transfectable cells, and prefer an intact vector. Conveniently deliver Cas9 Nickase and gRNA with a single vector. Reduce off-target activity. Drive Cas9 Nickase expression with the EF1α promoter, which provides medium expression levels in most cell types, including primary cells ...
Manufactured by:Obsidian Therapeutics, Inc. based inCambridge, MASSACHUSETTS (USA)
Our proprietary cytoDRiVE® platform leverages drug responsive domains (DRDs) to control protein function using an FDA-approved small ...
Manufactured by:Editas Medicine based inCambridge, MASSACHUSETTS (USA)
Genomic medicine is a developing field of medical research that harnesses recent advances in genetics to develop new medicines for diseases. In fact, we are at an inflection point where we are seeing the first real genomic medicines emerge to help patients. Advances in the scientific fields of cell therapy and gene therapy have paved the way for the success of ...
Manufactured by:Thermo Fisher Scientific based inWaltham, MASSACHUSETTS (USA)
Invitrogen TrueCut HiFi Cas9 Protein is a high fidelity CRISPR Cas9 protein variant engineered to demonstrate superior off-target profiles, while preserving maximum on-target editing efficiency. TrueCut HiFi Cas9 Protein is ideal for applications that are sensitive to off-target events and when more precise editing is ...
by:KeyGene based inWageningen, NETHERLANDS
Finding new ways to improve crops by developing and using cell and tissue technology in plant breeding. Innovations in cell and tissue culture technology provide exciting new opportunities to improve crops, particularly those that are difficult to regenerate or genetically transform. While regenerating plants from protoplasts or plant tissue is common in many crop improvement techniques, at ...
Manufactured by:Universal Cells Inc. based inSeattle, WASHINGTON (USA)
Universal Cells uses recombinant Adeno-Associated Virus (rAAV)-mediated gene editing to engineer chromosomal genes without the use of genotoxic nucleases. Serotype 3B rAAV vectors efficiently infect pluripotent stem cells and their single-stranded DNA genomes pair with homologous chromosomal sequences during replication to precisely alter human ...
Manufactured by:Indee Labs based inBerkeley, CALIFORNIA (USA)
Hydropore™ is a simple, scalable and efficient way to accelerate the discovery, development and manufacturing of gene-modified cell therapies (GMCTs) such as T cell immunotherapies. This novel, non-viral technology utilizes the power of microfluidic vortex shedding (µVS) to rapidly deliver nucleic acids, proteins and gene-editing complexes to immune cells in a matter of ...
Manufactured by:Agilent Technologies, Inc. based inSanta Clara, CALIFORNIA (USA)
The SureGuide gRNA Synthesis Kit is part of an integrated solution for in-vitro CRISPR/Cas research. Use this kit to generate high concentrations of gRNA, and combine with the SureGuide Cas9, or your own Cas9 protein, to clone complex genomic regions with high accuracy and specificity. The SureGuide gRNA kit shortens your time from planning to experiment, and reduces the cost of setting up your ...
Manufactured by:Agilent Technologies, Inc. based inSanta Clara, CALIFORNIA (USA)
The Cas9 endonuclease kit is part of an integrated solution for in-vitro CRISPR/Cas resesarch. Use this kit for in-vitro cloning of large genes or DNA fragments without the limitations imposed by common restriction enzymes or PCR fidelity. Allows cleavage of DNA at single and multiple locations based on a custom sequence of interest. Customizable endonuclease specificity, Higher specificity than ...