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In Vivo Gene Equipment & Supplies
12 equipment items found
Manufactured by:Brooklyn ImmunoTherapeutics (BTX) based inSan Diego, CALIFORNIA (USA)
The foundational technology of synthetic mRNA, precise gene-editing machinery, and non-viral delivery also enable the development of genetic medicines with curative potential for multiple disease states. Brooklyn is developing products designed to edit a patient’s genome inside their body and address diseases with clear genetic causation. ...
Manufactured by:Editas Medicine based inCambridge, MASSACHUSETTS (USA)
We are pursuing a number of diseases using an in vivo editing approach, focusing on hematopoietic stem cells and other tissue types, and we are excited about the progress we’ve ...
Manufactured by:Editas Medicine based inCambridge, MASSACHUSETTS (USA)
EDIT-301 is an experimental cell therapy medicine under investigation for the treatment of severe sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT). EDIT-301 consists of patient-derived CD34+ hematopoietic stem and progenitor cells edited at the gamma globin gene (HBG1 and HBG2) promoters, where naturally occurring fetal hemoglobin (HbF) inducing mutations reside, by a ...
Manufactured by:Catalent, Inc based inSomerset, NEW JERSEY (USA)
AAV, or adeno-associated virus, is considered the gold standard for in vivo gene delivery transfer and has become the leading viral vector choice for gene therapies today. As one of the field’s most effective delivery tools, AAV has shown strong clinical success and recent improvements in related technology and system approaches have made ...
Manufactured by:Catalent, Inc based inSomerset, NEW JERSEY (USA)
AAV, or adeno-associated virus, is considered the gold standard for in vivo gene delivery transfer and has become the leading viral vector choice for gene therapies today. As one of the field’s most effective delivery tools, AAV has shown strong clinical success and recent improvements in related technology and system approaches have made ...
Manufactured by:Genenta Science based inMilano, ITALY
After apheresis collection, a functional copy of the therapeutic gene is inserted into the patient’s own HSPCs using a non-replicating lentiviral vector. This is an ex-vivo process called transduction. We believe that LVVs are the first choice for ex-vivo gene therapy in humans because they can efficiently transduce HSPCs ...
Manufactured by:ViruSure GmbH based inVienna, AUSTRIA
Gene therapy has brought hope to many diseases with unmet clinical need. The potential to permanently cure the patient through replacement of a defective gene with a healthy gene underscores the surge of interest in this exciting biopharma ...
Manufactured by:Aldevron, LLC based inFargo, NORTH DAKOTA (USA)
The gWiz plasmids are designed for the highest level of gene expression in a wide range of mammalian cells and tissues. They contain a proprietary modified promoter, followed by intron A from the CMV immediate early gene, and a high-efficiency artificial transcription terminator. gWiz expression vectors are constructed using a plasmid backbone that has been extensively modified to achieve ...
by:TQ Therapeutics GmbH based inPlanegg, GERMANY
TQx is developing a modular target cell-specific modification platform including relevant technology components for the generation of gene modified cell therapy ...
Manufactured by:Lupagen Inc. based inDallas, TEXAS (USA)
Lupagen avoids the cost & complexity of cell therapy and the safety & clinical challenges of viral-based gene therapy by a simple patient-connected gene delivery procedure done at the bedside. Our Side CAR-T® delivery system, a first-in-class bedside system enables gene delivery directly to target cells in a highly-controlled and safe environment before reinfusing therapies to the ...
Manufactured by:Emulate based inBoston, MASSACHUSETTS (USA)
Drug-induced liver injury (DILI) is a primary concern during drug development that remains poorly understood due to species differences in liver toxicity and the limited predictivity of conventional in vitro models. The quad-culture Emulate Liver-Chip combines four human cell types in a dynamic microenvironment to support in vivo like gene expression, ...
Manufactured by:Emulate based inBoston, MASSACHUSETTS (USA)
Research mechanisms of neuroinflammation and evaluate the effect of therapeutics in a comprehensive model of the neurovascular ...