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Lupus Erythematosus Equipment & Supplies
43 equipment items found
by:Horizon Therapeutics plc based inSaint Kevin`s, IRELAND
A fully human monoclonal antibody against ILT7 that depletes certain dendritic cells. We are investigating daxdilimab in dermatomyositis, discoid lupus erythematosus and lupus nephritis as well conducting Phase 2 clinical trials in alopecia areata and systemic lupus ...
Manufactured by:D-tek s.a. based inMons, BELGIUM
These autoantibodies are diagnostic markers and classification criteria for Sjögren’s Syndrome. They are also associated with SLE and Subacute Cutaneous Lupus Erythematosus (SCLE) and present in 90 % of patients with Neonatal Lupus Erythematosus (NLE). ...
Manufactured by:Galapagos NV based inMechelen, BELGIUM
A TYK2 inhibitor for which topline results from the Phase 1b in psoriasis were reported in July 2021. Phase 2 studies in dermatomyositis and Systemic Lupus Erythematosus (SLE) are expected to start in ...
Manufactured by:D-tek s.a. based inMons, BELGIUM
Following the American College of Rheumatology (ACR), the presence of anti-dsDNA antibodies is one of the diagnostic criteria for Systemic Lupus Erythematosus (SLE). Indeed, they are reported to have a high pathogenic and diagnostic significance for SLE. They are among the most frequently detected autoantibodies associated with SLE. Moreover the dsDNA antibody ...
Manufactured by:ORGENTEC Diagnostika GmbH is part of the Sebia Group based inMainz, GERMANY
Regardless of their immunoglobulin class, cardiolipin autoantibodies are an important criterion for the diagnosis of APS. Autoantibodies against cardiolipin are also an immunological classification criterion for systemic lupus erythematosus (SLE). In addition, the quantitative determination of anti-cardiolipin is very useful for monitoring SLE patients with ...
Manufactured by:AROTEC Diagnostics Limited based inWellington, NEW ZEALAND
Autoantibodies directed to negatively charged phospholipids, in particular cardiolipin, have been detected in the serum of patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). APS is characterised by venous and arterial thrombosis, recurrent spontaneous abortions and thrombocytopenia. It is now known that a serum cofactor, ...
Manufactured by:ImmunoVision, Inc. based inSpringdale, ARKANSAS (USA)
Use of plasmid DNA in ELISA is an effective method for the detection of anti-double-stranded (ds) DNA antibodies (1). The presence of antibodies to dsDNA is included in the 1982 revised criteria for classification of Systemic Lupus Erythematosus (SLE) ...
Manufactured by:Galapagos NV based inMechelen, BELGIUM
GSK has all rights to these compounds, and Galapagos is eligible to receive milestones and up to double-digit royalties on global sales. In the course of 2013, GSK initiated Phase 2 studies with GSK2586184 (formerly GLPG0778) in systemic lupus erythematosus, chronic plaque psoriasis, and ulcerative colitis. In February 2014, GSK stopped the lupus ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Edecesertib (GS-5718) is a selective, potent, orally active IRAK-4 inhibitor. Edecesertib has anti-inflammatory activity. Edecesertib can be used for rheumatoid arthritis (RA) and lupus erythematosus (LE) ...
Manufactured by:AROTEC Diagnostics Limited based inWellington, NEW ZEALAND
These autoantibodies are also often detected in sera from patients with Raynaud’s phenomenon and occasionally in other rheumatic diseases such as systemic lupus erythematosus, Sjögren’s syndrome, and rheumatoid arthritis. ACA have also been reported to occur with high prevalence in patients with primary biliary cirrhosis, in patients with ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
RN486 is a potent, selective and orally active Btk inhibitor with an IC50 of 4.0 nM and a Kd of 0.31 nM. RN486 is less active for other kinases. RN486 can be used for rheumatoid arthritis and systemic lupus erythematosus ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 (TLR7/9) ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Mefloquine hydrochloride is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine hydrochloride can be used for malaria, systemic lupus erythematosus and cancer ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Obexelimab works by inhibiting B cell receptor (BCR) mediated calcium influx and promoting the phosphorylation of Fc γ receptor IIb (FcγRIIb), which reduces B cell activation and function, leading to B cell apoptosis. Obexelimab can be used in research for rheumatoid arthritis and systemic lupus ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sjögren’s syndrome and type I diabetes ...
Manufactured by:DxTerity Diagnostics Inc. based inRancho Dominguez, CALIFORNIA (USA)
Modular transcriptome repertoire analysis 1, also known as modular genomics, shows tremendous promise for improving the characterization of patients with autoimmune diseases such as Systemic Lupus Erythematosus (SLE)7, Multiple Sclerosis (MS), Inflammatory Bowel Disease (IBD), and Rheumatoid Arthritis (RA) by providing biological insight into the underpinnings of ...
Manufactured by:D-tek s.a. based inMons, BELGIUM
Nucleosome consists of a sequence of DNA wrapped around a Histone octamer. They are responsible of the compactness of DNA in the ...
Manufactured by:Boston Pharmaceuticals based inCambridge, MASSACHUSETTS (USA)
BOS161721 (avizakimab) is a fully human anti-IL-21 ...