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Therapeutic Candidate Equipment & Supplies
38 equipment items found
Manufactured by:Regeneron Pharmaceuticals Inc. based inTarrytown, NEW YORK (USA)
elociT™ is our unique mouse technology for producing fully human therapeutic T-cell receptors (TCR) against tumor and viral antigens. Regeneron uses this technology as part of its efforts to discover and develop novel immuno-oncology therapeutic candidates, including combination approaches and to assist our collaborators in producing fully ...
Manufactured by:ZIND Verfahrenstechnik based inMainz, GERMANY
At pilot stage, the primary membrane candidate has been chosen, as process parameters. Typically at this stage, the production method is being verified and production materials produced for toxicology or pre-clinical trials and predictable scalability is imperative. In order to facilitate the manufacturing life cycle of a successful therapeutic ...
by:Sutro Biopharma Inc. based inSouth San Francisco, CALIFORNIA (USA)
Using cell-based expression systems to produce protein variants is also a cumbersome way to enable selection of the best therapeutic ...
Manufactured by:Ocugen, Inc. based inMalvern, PENNSYLVANIA (USA)
OCU410 (AAV-RORA) is a modifier gene therapy product candidate being developed for the treatment of dry age-related macular degeneration (Dry AMD). OCU410 utilizes an AAV delivery platform for the retinal delivery of the RORA (RAR Related Orphan Receptor A) gene. Various genes associated with AMD are regulated by RORA. The RORA protein plays an important role in lipid metabolism ...
Manufactured by:Catalent, Inc based inSomerset, NEW JERSEY (USA)
To date, over 600 different mAb and mAb fusions and over 160+ different recombinant proteins have been produced using the GPEx system, with 160+ clinical trials utilizing therapeutic candidates developed using GPEx technology and 16 commercially-approved products. ...
Manufactured by:Lung Therapeutics, Inc. based inAustin, TEXAS (USA)
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by progressive tissue scarring that prevents proper lung function. LTI-03 operates through a novel mechanism of action (MOA) that is unlike any MOA seen in the therapeutic candidates of today. By targeting healthy epithelial cells, LTI-03 promotes the protection of lung epithelium while ...
Manufactured by:Vascugen Inc. based inMadison, WISCONSIN (USA)
Development of complex iPSC-based therapeutics benefits from an engineering mindset. Each layer of the development and manufacturing process is considered part of the ‘Full Stack’ that leads to finished product. An integrated stepwise approach improves the probability of arriving at the right therapeutic candidate and reduces ...
Manufactured by:TC BioPharm based inHolytown, UNITED KINGDOM
GDT cells are a component of the lymphocytes (white blood cells) present within all humans, representing approximately 1-5% of the circulating population. As part of the immune system's innate response, their natural properties make them promising therapeutic candidates. This review demonstrates the historical work on GDT cell therapies, and the promise offered ...
by:Pure Biologics SA based inWroclaw, POLAND
Therapies targeting immunological checkpoints, or more specifically their inhibition, promise effective treatment options for patients with metastatic forms of this disease. In the PB001 project, Pure Biologics aims to develop a recombinant bispecific antibody as a therapeutic candidate for immunotherapy in colorectal ...
Manufactured by:Siolta Therapeutics based inSan Carlos, CALIFORNIA (USA)
Siolta’s Precision Symbiotics Platform enables rapid LBP development. A platform focused on translating microbiome science into novel therapeutics for a healthier world. Siolta’s patient-centric platform leverages our internal expertise in microbiome data analysis, machine learning, anaerobic microbiology, and translational studies to rationally design and optimize ...
by:Sibylla Biotech S.p.A. based inVerona, ITALY
What makes us unique is the power of our computational platform, which enables us to reconstruct the series of conformational rearrangements underlying the process of protein folding at an atomistic level of ...
by:Ainovo Biotech Inc. based inSacramento, CALIFORNIA (USA)
AlOptimus™ brings to bear AINovo's proprietary machine learning algorithms on our highly curated datasets to enhance the therapeutic profiles of drug candidates. The AlOptimus platform optimizes validated candidates to derisk development and inform clinical ...
Manufactured by:VECT-HORUS based inMARSEILLE, FRANCE
In other words, Vect-Horus’ core expertise relies on modifying pharmacokinetic (PK) and distribution profile of therapeutic or imaging candidates. ...
Manufactured by:Rocket Pharmaceuticals, Inc. based inCranbury, NEW JERSEY (USA)
The LVV platform is ideal for modifying hematopoietic stem cells (HSCs) to address disorders affecting the bone marrow. The LVV transduction process occurs ex vivo (outside the body), which ensures that the gene has been properly integrated before the therapy is given to the patient. The process involves collection and isolation of a patient’s hematopoietic stem cells ...
Manufactured by:Rocket Pharmaceuticals, Inc. based inCranbury, NEW JERSEY (USA)
The LVV platform is ideal for modifying hematopoietic stem cells (HSCs) to address disorders affecting the bone marrow. The LVV transduction process occurs ex vivo (outside the body), which ensures that the gene has been properly integrated before the therapy is given to the patient. The process involves collection and isolation of a patient’s hematopoietic stem cells ...
by:Redbiotec AG based inSchlieren, SWITZERLAND
Redbiotec specializes in developing high-quality vaccines to fight difficult diseases. After successfully spinning out the CMV vaccine program that was acquired by Pfizer, Redbiotec is currently developing HSV-2 therapeutic vaccine ...
Manufactured by:Codexis, Inc. based inRedwood City, CALIFORNIA (USA)
Achieve exceptional IVT results with Codex® HiCap RNA Polymerase, a co-transcriptional capping RNA polymerase that has been uniquely engineered to produce synthetic mRNA at high yield and low ...
Manufactured by:Mimetas B.V. based inLeiden, NETHERLANDS
Profiling and screening of your compounds with a high throughput barrier integrity assay on our established Caco-2 intestinal model. OrganoServices are available for multiple assays to allow compound profiling and/or screening in human-relevant, complex 3D tissue models. When developing new drugs, it is critical to understand the permeability, absorption, and transport mechanisms in relevant ...
Manufactured by:Ncardia Services B.V. based inLeiden, NETHERLANDS
Disturbances in calcium signaling are associated with many neurodegenerative diseases and cardiomyopathies. Fluorescence-based assays with iPSC-derived cardiac and neuronal models can be used to monitor short and long-term drug-induced changes on calcium transients. Our scientists develop the most optimal calcium transient assay for each project and can scale it up for high-throughput screening, ...
Manufactured by:Newcells Biotech Limited based inNewcastle Upon Tyne, UNITED KINGDOM
Human lung fibroblast model to test the efficacy of anti-fibrotic agents in vitro. Newcells human primary lung fibroblast model is the basis of our FMT assay to evaluate anti-fibrotic therapies in vitro at high throughput. The assay replicates extracellular matrix deposition (ECM) observed in vivo when lung fibroblast injury leads to activation and proliferation. Following injury, pulmonary ...