SILKBridge - Tissue Engineered Technology
KLISBio is developing SILKBridge: a tissue engineered technology based on pure silk fibroin that has the potential to show an optimized balance between biomechanical and biological properties, complementing the high strength of native silk fibers and the enhanced biomimicry of electrospun silk. It is intended for the surgical repair of peripheral nerve discontinuities to support regeneration across the defect.
Products Details
Reworking the literature from a modern perspective, we developed a silk-based multidisciplinary technology platform able to generate products and solutions for a variety of clinical indications, such as peripheral nerve injuries, peripheral vascular diseases, bone defects, tendon tears and situations where a sustained drug release is needed.
Patents
Patent granted in Italy (2016), Europe (2018). Pending in the US, China and others
In-licensed patent granted in 2018, plus new IP under development
Italian patent granted (2019) and PCT extension submiRed (2018)
Why Silk
We merged a deep-rooted cultural tradition and know-how with the most advanced technologies creating a highly purified material needed for biomedical applications, without the need for chemical cross-linking reactions that alter the protein.
The advanced technological approach we use to transform the raw material into the final medical device allows silk to remain pure from the beginning to the end of the process.
- Outstanding mechanical and biological properties
- Versatile processing options
- Programmed degradation profiles
- Free from cells, nuclear remnants or genetic material
- Favorable morphological, chemical, and mechanical cues for cells to grow on
- FAVORS ANGIOGENESIS
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