Lattice - Soft Tissue Reconstruction Technology
From Technology
Lattice Medical is a biomedical start-up that was launched in October 2017; Patented 3D technology developed with CHU Lille-France that allows adipose tissue to naturally regenerate.
Technology Overview
1. Breast cancer touch 1 in 8 women in the world In 40% of cases, mastectomy is the usual treatment followed by chemotherapy or radiotherapy Only 14% of women receive reconstructive surgery
2. Reconstruction procedure offered are:
silicon prosthesis, autologous fat tissues grafting by microsurgical technics (DIEP) or non-vascularise transfer (lipofilling).
These methods show different issues such as multiple surgical procedure, complications and costs for healthcare system, limiting the availability for patients.
3. LATTICE MEDICAL, valorising 6 research years from CHU Lille, comes up with an innovative technical solution combining the advantages of current techniques, thereby simplifying the process and making it more accessible and less expensive: a 3D printed bioabsorbable implant called MATTISSE.
4. The technology involves the use of autologous adipose tissue as a base, and then combines this with a 3D printed absorbable implant, thereby making it possible to get the desired size with just one operation. This implant helps the patient’s fat cells regenerate.
5. MATTISSE is made up of two 3D printed bioabsorbable parts: the first, inspired by Calais laces, provides support for the fat, and the second is a shell giving the volume and the shape reconstruction.
The use of 3D printing makes it possible, using MRI or CT-scan images, to design a personalised implant to restore former breast.
6. Autologous fat tissues are placed on the support material. It helps guide tissue reconstruction during 4 to 8 months. Meanwhile, the bioabsorbable implant will slowly degrade, until full resorption in one year. The breast is thus entirely rebuilt by the patient’s tissues, without introducing any foreign bodies.
7. LATTICE MEDICAL’s ambition is to make and commercialize the implant for reconstruction and plastic surgery markets by 2023. The product is in the pre-clinical development stage and be tested in a first clinical breast reconstruction trial in 2021.
8. The breakthrough innovation that Lattice Medical has developed was made possible by combining different skillsets in the textile materials industry, including through UP-tex, in connection with the medical and university team of CHU Lille and of Lille University.
Since January 2017, Lattice Medical has been in incubation at Eurasanté and receiving financial support from the Hauts-de-France region as well as from BPIFrance.
Applications
RESORBABLE CHAMBER
- Designed and made with 3D printed biomaterials
- Adapted to the individual morphology of patients
- Fully degrades in a year
PATIENT AUTOLOGOUS ADIPOSE TISSUE GRAFTING
- Vascular adipose flap tissue inlaid over the Tissue Engineering Chamber (TEC)
- Guided tissue reconstruction
- Regenerates patients’ adispose cells
Subcutaneous Tissue and Facial Reconstruction
Lattice Medical also provides solutions for improving tissue engineering and regenerative medicine using 3D-printed bio-resorbable scaffolds.
Following surgery, serious burns, chronic wounds, and accidents, traumatized soft tissue needs to be repaired.
In collaboration with CHU Lille, Lattice Medical provides product design, R&D services, and various solutions for soft tissue engineering and regeneration. Alongside textile manufacturing partners, we develop textile matrixes (including Calais lace ones) that are obtained through the Leavers method.
Lattice Medical offers sub-licensing R&D contracts to manufacturers and provides pre-clinical proof-of-concept studies.
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