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GS-International - Model CAS-137-58-6 - Lidocaine
Chloroacetyl chloride method 2,6-dimethylaniline is chloroacetylated with chloroacetyl chloride, then condensed with diethylamine, and then acidified to obtain lidocaine.2. Diethylaminoacetic acid methyl ester method In the presence of sodium methoxide, 2,6-dimethylaniline is condensed with N,N-diethylacetic acid methyl ester, and then acidified to obtain the product.Uses: This product is an amide local anesthetic. It is widely used in surface anesthesia, infiltration anesthesia, conduction anesthesia and epidural anesthesia.
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intravenous use
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- Molecular Formula: C14H22N2O
- Molecular Weight: 234.34 g/mol
- Appearance: White or off-white crystalline powder (HCl form); odorless with a bitter taste
- Melting Point: 66–69°C (base); 75–79°C (HCl)
- Boiling Point: 350.8°C (at 760 mmHg, base)
- Density: ~1.0 g/cm³ (predicted)
- Refractive Index: 1.520–1.525
Primary Medical Uses:
- Local Anesthesia: Infiltration, nerve block, spinal, and topical anesthesia (e.g., skin, mucous membranes)
- Antiarrhythmic: Treatment of ventricular arrhythmias
- Analgesia: Intravenous use for perioperative pain management
Industrial Applications:
- Research Reagent: Used in molecular biology and pharmacology studies
- Chemical Synthesis: Precursor for metal complexes (e.g., iron, zinc) and deep eutectic solvents (DES)
Biochemical Activity:
- Substrate for CYP3A4 metabolism (produces monoethylglycinexylidide, MEGX)
- Inhibits histamine H1 receptors (reverse agonism)