Stanford Chemicals -Model 040-000-285 -Losartan Potassium, CAS 124750-99-8
Losartan competes with the binding of angiotensin II to AT1 receptors. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM. Losartan (40 μM) affects ISC but prevents the effect of ANGII on ISC. Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone.
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- Synonyms: 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt
- Key words: COVID-19, blood pressure, diabetic kidney disease, heart failure
- Related products: Hydroxychloroquine sulfate, Remdesivir
- Product Name: Losartan Potassium
- CAS Registry Number: 124750-99-8
- Molecular Formula: C22H22ClKN6O
- Molecular Weight: 461 g/mol
- Purity: >99 %
- Package: 1kg-25kg
- Solubility: DMSO : ≥ 110 mg/mL (238.61 mM)
- H2O : 33.33 mg/mL (72.30 mM; Need ultrasonic)
- Shelf life: 2 years
- Functions: Treatment of high blood pressure, diabetic kidney disease, heart failure, etc.
Losartan is a medication mainly used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. It may be used alone or in addition to other blood pressure medication. Up to six weeks may be required for the full effects to occur.
