LT-Hematopoietic Stem Cells

We are developing human long-term hematopoietic stem cells (LT-HSCs) from human (non-embryo) induced pluripotent stem cells (iPSCs). HSCs are rare subsets of hematopoietic cells that are responsible for the life-long production of all blood cell lineages, and for the reconstitution of bone marrow (BM) after transplantation into myeloablative recipients. We will use our LT-HSCs cells as the foundation for cell therapy for bone marrow failure, which we are developing, in particular, as a cell replacement therapy — in lieu of a bone marrow transplant — for patients whose bone marrow stems cells have been permanently damaged or destroyed.