LVOCheck - Biomarker
Large Vessel Occlusion strokes (LVO strokes) are ischemic strokes in which a large artery of the brain gets obstructed by a thrombus (blood clot). Among the different kinds of strokes, LVOs are the most prevalent, reaching 40% of all stroke patients. LVOs alone lead to 95% of all disabilities caused by strokes. Today LVOs can be treated by mechanical thrombectomy, the mechanical removal of the thrombus operated with a catheter.
An accurate and rapid triage of LVO affected patie...
An accurate and rapid triage of LVO affected patients is critical during the acute phase to take the patient rapidly to the reference hospital where he/she can receive the treatment as soon as possible. The treatment for LVO, thrombectomy, can only be performed in specialized hospital (comprehensive stroke centers). Nowadays, the ambulance brings the patient to the closest primary hospital that is not necessarily equipped to perform it. LVO diagnosis is mainly based on brain imaging data by computerized tomography (angio-CT-scan). If LVOs are detected, the patient must be sent with another ambulance to the reference hospital to get the thrombectomy. The time required for the primary diagnosis and transportation takes from 1 to 2 hours: such extended periods of time in stroke diagnosis are correlated with increased risk of death, of poor outcome, or of longer rehabilitation time.
The Unmet Need
A widely available and user-friendly rapid biochemical test would help manage the highly critical phase of the pre-hospital triage and management of stroke patients, allowing to perform thrombectomy quicker, thus improving the rates of recovery of ischemic stroke patients drastically.
ABCDx has identified a combination of biomarkers highly efficient to achieve a rapid, accurate diagnosis of LVO with a portable device that can be used in ambulances, called the LVOCheck, to speed up access to thrombectomy.
LVOCheck allows to reduce the time currently required to diagnose and treat LVO by providing an accurate identification of LVO directly in the ambulance within 10 minutes. If the LVO is detected, the ambulance can drive the patient directly to the reference hospital to get a thrombectomy in a much shorter time, saving up to 2 hours compared to the current protocols.
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