Meissa - COVID-19 Live Attenuated Vaccine Candidate
Meissa is developing a live attenuated COVID-19 vaccine candidate, MV-014-212, to induce mucosal and systemic immunity and protect against SARS-CoV-2, the novel coronavirus that causes COVID-19. Like Meissa’s RSV vaccine candidate, MV-014-212 offers significant potential advantages for global deployment, including needle-free intranasal administration, a single adjuvant-free dose to induce mucosal and systemic immunity, as well as a straightforward, economical, and scalable manufacturing process. A Phase 1 clinical study has been initiated in the U.S. to evaluate the safety, tolerability, and immunogenicity of a single intranasal dose of MV-014-212 (ClinicalTrials.gov identifier: NCT04798001).
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Preclinical data in nonhuman primates (NHPs) of MV...
Preclinical data in nonhuman primates (NHPs) of MV-014-212 demonstrate that a single adjuvant-free dose of MV-014-212 provided equivalent protection against SARS-CoV-2 challenge compared to reported efficacy in NHP models of currently authorized vaccines. Furthermore, the data show that MV-014-212 stimulates mucosal (nasal IgA) antibodies in the upper respiratory tract, the major infection route for SARS-CoV-2, and systemic (serum neutralizing and binding IgG) antibodies. The mucosal immune response is the first line of defense against respiratory viruses, providing fast-acting protection at the primary site of exposure. In NHPs, Meissa’s intranasal COVID-19 vaccine generated both mucosal and systemic antibodies and was highly protective against wild-type SARS-CoV-2 challenge. Serum antibodies were able to neutralize wild-type SARS-CoV-2, B.1.351 (Beta, South Africa), and B.1.1.7 (Alpha, UK). Additional data from serial passaging in manufacturing cell line and virus shed from NHPs showed that MV-014-212 has a stable genotype in vitro and in vivo (download the manuscript and supplemental material).
SARS-CoV-2 Variants
Vaccines against SARS-CoV-2 and emerging variants will be needed on an ongoing basis so long as SARS-CoV-2 circulates. Meissa’s MV-014-212 stimulates cross-neutralizing serum antibodies against SARS-CoV-2 variants of concern. Furthermore, our AttenuBlock platform is amenable to generation of vaccine constructs to combat future variants as needed.
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