SPACEGEN - MGMT Gene Methylation Detection Kit (Mutiplex Fluorescence PCR)

Methylguanine DNA-Methyltransferase (MGMT) is a highly effective DNA repair enzyme that can repair damage to the DNA of tumor cells caused by alkylating agents in chemotherapy and if the MGMT activity in tumor cells reaches a certain level, it may lead to drug resistance.
MGMT's repair function of alkylating agent damage enables it to play a dual role in tumor chemotherapy: First, it protects normal tissue from alkylating agent damage and secondary cancer; Second, it causes the resistance of tumor tissue to alkylating agent chemotherapy drugs. MGMT's repair of alkylating agent damage enables it to play a dual role in tumor chemotherapy: First, it protects normal tissue from alkylating agent damage and secondary cancer; second, it causes the resistance of tumor tissue to alkylating agent chemotherapy drugs.

DNA methylation is closely related to the occurrence and development of brain glioma. The "Tumor Individualized Therapy Detection Technique Guideline" indicates that glioblastoma patients with methylated MGMT promoter benefit from Temozolomide.

Core Technology:PAP-ARMS®

Applicable Disease:Glioma

Instruments Validated:ABI7500, ABI7300, ABI StepOne Plus, LightCycler480, Bio-Rad CFX96, etc.

Sample Type:Tumor tissue

Qualification:ISO13485 certificate, CAP，CE marking

 Pack Size:24 Tests/Kit

MGMT methylation suggests sensitivity to Temozolomide chemotherapy, which is helpful for clinical formulation of appropriate treatment

MGMT methylation suggests a better prognosis

Glioma WHO III/IV glioma patients or before chemotherapy treatment.

1.Accurate and reliable: Closed tube detection without product post-processing.

2.Simple operation: Only one step, 90 minutes to complete the test.

3.Good repeatability: The ordinary PCR laboratory can be carried out, and no special training is required to obtain good repeatability results.

4.Advanced technology: Developed based on proprietary PAP-ARMS® technology.